This set of Biochemistry Multiple Choice Questions & Answers (MCQs) focuses on “Gluconeogenesis”.
1. Which of the following is not an important precursor of glucose in animals?
a) Lactate
b) Pyruvate
c) Glycerol
d) Glucose 6-phosphate
View Answer
Explanation: The important precursors of glucose in animals are three-carbon compounds such as lactate, pyruvate and glycerol as well as certain amino acids.
2. Which of the following statements is false about gluconeogenesis?
a) From the hydrolysis of tri-acyl-glycerol, fatty acids can be used as a carbon source
b) From red blood cells, lactate can be used as a carbon source
c) From the hydrolysis of tri-acyl-glycerol, glycerol is converted to glucose in gluconeogenesis
d) From muscle vigorous muscle activity, lactate can be used as a carbon source
View Answer
Explanation: From the hydrolysis of tri-acyl-glycerol, fatty acids cannot be used as a carbon source.
3. Which enzyme catalyzes the conversion of pyruvate to oxaloacetate?
a) Pyruvate carboxylase
b) Pyruvate dehydrogenase
c) Pyruvate kinase
d) Phosphofructokinase-1
View Answer
Explanation: Pyruvate carboxylase requires the coenzyme biotin to convert pyruvate to oxaloacetate.
4. Oxaloacetate is reduced to malate by ____________
a) Pyruvate carboxylase
b) Malate dehydrogenase
c) Pyruvate kinase
d) Phosphofructokinase-1
View Answer
Explanation: Oxaloacetate formed from pyruvate is reduced to malate by malate dehydrogenase.
5. Gluconeogenesis involves the conversion of ____________
a) Glucose to pyruvate
b) Pyruvate to glucose
c) Phosphoenolpyruvate to glucose
d) Pyruvate to fructose
View Answer
Explanation: Gluconeogenesis is the process of conversion of pyruvate to glucose whereas glycolysis is the process of conversion of glucose to pyruvate.
6. Which of the following organisms cannot convert acetyl-coA derived from fatty acids into glucose?
a) Animals
b) Plants
c) Bacteria
d) Virus
View Answer
Explanation: Animals cannot convert acetyl-coA derived from fatty acids into glucose; plants and microorganisms can.
7. Formation of one molecule of glucose from pyruvate requires ____________
a) 4 ATP, 2 GTP and 2 NADH
b) 3 ATP, 2 GTP and 2 NADH
c) 4 ATP, 1 GTP and 2 NADH
d) 2 ATP, 2 GTP and 2 NADH
View Answer
Explanation: Formation of one molecule of glucose from pyruvate requires 4 ATP, 2 GTP and 2 NADH.
8. Ethanol is oxidized to acetaldehyde in the liver cytoplasm by ____________
a) Alcohol dehydrogenase
b) Alcohol carboxylase
c) Pyruvate carboxylase
d) Pyruvate kinase
View Answer
Explanation: Ethanol is oxidized to acetaldehyde in the liver cytoplasm by alcohol dehydrogenase which is the converted to acetate.
9. What is the main source of glucose carbons for gluconeogenesis?
a) Guanine
b) Alanine
c) Cysteine
d) Threonine
View Answer
Explanation: The main source of glucose carbons for gluconeogenesis is alanine derived from the breakdown of muscle proteins.
10. Which of the following statements about gluconeogenesis is correct?
a) Pyruvate is first converted to phosphoenolpyruvate by phosphoenolpyruvate carboxykinase
b) Fructose 1, 6-biphosphatase converts fructose 1, 6-bisphosphate into fructose 1-phosphate
c) Glucose 6-phosphatase hydrolyzes glucose 6-phosphate to release glucose into the blood
d) Glucose 6-phosphatase hydrolyzes glucose 6-phosphate and is found in liver and muscle
View Answer
Explanation: Glucose 6-phosphate is hydrolyzed by glucose 6-phosphatase to release glucose into blood.
Sanfoundry Global Education & Learning Series – Biochemistry.
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