This set of Biochemistry Multiple Choice Questions & Answers (MCQs) focuses on “Biosynthesis and Degradation of Nucleotides”.
1. An amino group donated by glutamine is attached at C-1 of PRPP, this results in ____________
a) 5-phosphoribosylamine
b) 4-phosphoribosylamine
c) 3-phosphoribosylamine
d) 2-phosphoribosylamine
View Answer
Explanation: An amino group donated by glutamine is attached at C-1 of PRPP, this results in 5-phosphoribosylamine.
2. The first intermediate with a complete purine ring is ____________
a) Inosinate
b) Formate
c) Aspartate
d) Glycine
View Answer
Explanation: The first intermediate with a complete purine ring is inosinate.
3. Which of the following is an important precursor in the purine pathway?
a) Glycine
b) Aspartate
c) Glutamine
d) Leucine
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Explanation: Aspartate is important precursor in pyrimidine pathway.
4. Which of the following is an important precursor in pyrimidine pathway?
a) Glycine
b) Aspartate
c) Glutamine
d) Leucine
View Answer
Explanation: Glycine is an important precursor in purine pathway.
5. In the first committed step of pyrimidine biosynthesis, the reaction is catalyzed by ____________
a) Adenylate kinase
b) Aspartate transcarbamoylase
c) Dihyhroorotase
d) Cytidylate synthase
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Explanation: Carbamoyl phosphate reacts with aspartate to yield N-carbamoylaspartate in the first committed step of pyrimidine biosynthesis catalyzed by aspartate transcarbamoylase.
6. Phosphorylation of AMP to ADP is promoted by ____________
a) Adenylate kinase
b) Aspartate transcarbamoylase
c) Dihyhroorotase
d) Cytidylate synthase
View Answer
Explanation: Phosphorylation of AMP to ADP is promoted by adenylate kinase.
7. CTP is formed from UTP by the action of ____________
a) Adenylate kinase
b) Aspartate transcarbamoylase
c) Dihyhroorotase
d) Cytidylate synthase
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Explanation: CTP is formed from UTP by the action of cytidylate synthase.
8. Conversion of dUMP to dTMP is catalyzed by ____________
a) Thymidylate synthase
b) Dihydrofolate reductase
c) Dihyhroorotase
d) Cytidylate synthase
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Explanation: Conversion of dUMP to dTMP is catalyzed by thymidylate synthase.
9. Adenosine deaminase deaminates adenosine to ____________
a) Hypoxanthine
b) Inosine
c) Xanthine
d) Guanosine
View Answer
Explanation: Adenosine is deaminated to inosine by adenosine deaminase.
10. Which of the following is degraded to methylmalonyl semialdehyde?
a) Glutamine
b) Tyrosine
c) Thymine
d) Leucine
View Answer
Explanation: Thymine is degraded to methylmalonyl semialdehyde.
Sanfoundry Global Education & Learning Series – Biochemistry.
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