Biochemistry Questions and Answers – The Structure Of Chromosomes

This set of Biochemistry Multiple Choice Questions & Answers (MCQs) focuses on “The Structure Of Chromosomes”.

1. The DNA threads which appear inside the nucleus at the time of cell division?
a) Spindle fibers
b) Centrioles
c) Asters
d) Chromosomes
View Answer

Answer: d
Explanation: Chromosome is a thread-like DNA structure carrying genetic information in the form of genes.

2. Which of the following is not a major class of chromatin proteins?
a) Histones
b) Topoisomerases
c) SMC proteins
d) Cohesins
View Answer

Answer: d
Explanation: Cohesins are the proteins in the SMC family.

3. Which of the following plays a substantial role in linking together sister chromatids immediately after replication?
a) Cohesins
b) Condensins
c) Histones
d) Topoisomerases
View Answer

Answer: a
Explanation: The cohesins play a substantial role in linking together sister chromatids immediately after replication and keeping them together as the chromosomes condense to metaphase.
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4. Which of the following are essential to the condensation of chromosomes as cells enter mitosis?
a) Cohesins
b) Condensins
c) Histones
d) Topoisomerases
View Answer

Answer: b
Explanation: Cohesins are important immediately after replication.

5. Chromatin is composed of ____________
a) DNA
b) DNA and proteins
c) DNA, RNA and proteins
d) None
View Answer

Answer: c
Explanation: DNA + histones combination is termed as chromatin.

6. Which of the following histones bind to linker DNA?
a) H1
b) H2A
c) H2B
d) H3
View Answer

Answer: a
Explanation: The bead of each nucleosome contains eight histone molecules: two copies each of H2A, H2B, H3 and H4.

7. Which of the following has beads on a string structure?
a) Chromosomes
b) Chromatin
c) Nucleosomes
d) Heterochromatin
View Answer

Answer: c
Explanation: DNA winds around histone proteins forming nucleosomes: the beads on a string structure.
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8. Which of the following histones shows more sequence similarity among eukaryotic species?
a) H1
b) H2A
c) H2B
d) H3
View Answer

Answer: d
Explanation: The H3 histones are nearly identical in amino acid sequence in all eukaryotes, as are the H4 histones.

9. The sister chromatids separate at ____________
a) Prophase
b) Metaphase
c) Telophase
d) Anaphase
View Answer

Answer: d
Explanation: During anaphase, each chromosomal pair is separated into two identical and independent chromosomes.
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10. Cellular DNA is uncondensed throughout ____________
a) Prophase
b) Interphase
c) Telophase
d) Anaphase
View Answer

Answer: b
Explanation: During interphase, the cell’s DNA is not condensed.

Sanfoundry Global Education & Learning Series – Biochemistry.

To practice all areas of Biochemistry, here is complete set of 1000+ Multiple Choice Questions and Answers.

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Manish Bhojasia - Founder & CTO at Sanfoundry
Manish Bhojasia, a technology veteran with 20+ years @ Cisco & Wipro, is Founder and CTO at Sanfoundry. He lives in Bangalore, and focuses on development of Linux Kernel, SAN Technologies, Advanced C, Data Structures & Alogrithms. Stay connected with him at LinkedIn.

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