This set of Biochemistry Question Bank focuses on “Biosynthesis of Cholesterol, Steroids and Isoprenoids”.
1. Generally, the receptors for steroid hormones reside at ___________
a) Nucleoplasm
b) Nuclear membrane
c) Cytoplasm
d) Plasma membrane
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Explanation: The receptors for steroid hormones reside at nucleoplasm.
2. Steroids have ___________
a) Sterol nucleus with two alkyl chain attached to the ring D of cholesterol
b) Sterol nucleus with two CH3 between C and D ring and A and B ring of cholesterol
c) Sterol nucleus without CH3 between C ring and D ring of cholesterol
d) Sterol nucleus but lack the alkyl chain attached to the ring D of cholesterol
View Answer
Explanation: Steroids have a sterol nucleus but lack the alkyl chain attached to the ring D of cholesterol.
3. Prednisolone and prednisone are chemically ___________
a) Steroids
b) Glycerol derivatives
c) Non-steroid anti-inflammatory drug
d) Amino alcohols
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Explanation: Prednisolone and prednisone are chemically steroids.
4. The essential intermediates in the pathway from acetate to cholesterol are ___________
a) Acetic acid
b) Ethylene
c) Isoprene units
d) Methane
View Answer
Explanation: Isoprene units are the essential intermediates in the pathway from acetate to cholesterol.
5. Which is the first intermediate in cholesterol synthesis?
a) Mevalonate
b) Isoprene
c) Squalene
d) Ethylene
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Explanation: The first intermediate in cholesterol synthesis is mevalonate.
6. How many carbons are present in HMG co-A?
a) 2
b) 3
c) 5
d) 6
View Answer
Explanation: Two molecules of acetyl co-A condense to form acetoacetyl co-A, which condenses with the third molecule of acetyl co-A to yield a six-carbon compound HMG co-A.
7. Which of the following is the major point of regulation on the pathway to cholesterol?
a) Thiolase
b) HMG co-A synthase
c) HMG co-A reductase
d) Pyruvate kinase
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Explanation: HMG co-A reductase is the major point of regulation on the pathway to cholesterol.
8. Which of the following is the integral membrane protein of smooth ER?
a) Thiolase
b) HMG co-A synthase
c) HMG co-A reductase
d) Pyruvate kinase
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Explanation: HMG co-A reductase is the integral membrane protein of smooth ER.
9. How many carbons are present in geranyl pyrophosphate?
a) 8
b) 9
c) 10
d) 11
View Answer
Explanation: Geranyl pyrophosphate is a 10-carbon chain.
10. Which of the following regulates the female reproductive cycle?
a) Progesterone
b) Testosterone
c) Estrogens
d) Glucocorticoids
View Answer
Explanation: Testosterone and estrogens which influence the development of secondary sexual characteristics in males and females, respectively.
Glucocorticoids help regulate gluconeogenesis and reduce the inflammatory response.
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