This set of Pharmaceutical Biotechnology Multiple Choice Questions & Answers (MCQs) focuses on “Barriers to Protein and Peptide Delivery”.
1. Which of the following is not a barrier for protein and peptide delivery?
a) Blood Brain Barrier
b) Enzymatic Barrier
c) Epidermal Barrier
d) Capillary Endothelial Barrier
View Answer
Explanation: Epidermal Barrier is an effective physical barrier which prevents dehydration to takes place in our body and also functions as a heat regulator. All the other options including the Intestinal Epithelial barrier are considered as barriers for protein/peptide delivery.
2. Blood Brain Barrier (BBB) is involved in the transportation of protein drugs to various compartments of brain.
a) True
b) False
View Answer
Explanation: The Blood Brain Barrier is a selective permeable membrane which, in general, acts as a protective layer in order to prevent the entry of toxins that may cause brain damage. The BBB also regulates the transportation of protein molecules to brain compartments.
3. Which of the following barrier is more suitable for GI protein/peptide delivery?
a) Intestinal Barrier
b) Enzymatic Barrier
c) Capillary Endothelial Barrier
d) Blood Brain Barrier
View Answer
Explanation: Enzymatic Barrier is one of the major border membranes of epithelial cells that has wide specificity for protein molecules to degrade. Hence it is more suitable for protein/peptide delivery in Gastrointestinal tract.
4. Through which cellular mechanism water is absorbed predominantly from the intestinal lumen?
a) Transcytosis
b) Pinocytosis
c) Carrier mediated transport
d) Paracellular movement
View Answer
Explanation: Paracellular movement is a type of Passive transport which substantially mediates the regulation and transportation of hydrophilic molecules across membranes varying in cellular concentration.
5. When proteins/peptides are more likely to undergo proteolytic attacks?
a) Upon the absence of stereoisomers
b) While the rate and site of hydrolysis of peptide bonds are affected
c) Due to increased side-chain length of the peptides
d) Due to low bioavailability
View Answer
Explanation: Proteolytic attack is caused by an enzyme called protease that breaks down the protein molecules to smaller peptides by cleaving them. This involves changing the rate and site of hydrolysis of peptide bonds.
6. Which of the following is a non-parenteral mode of protein drug administration?
a) Intramuscular
b) Intravenous
c) Transdermal
d) Subcutaneous
View Answer
Explanation: All the other options describe parenteral mode of drug administration which is mainly considered for systemic delivery of proteins to attain maximum therapeutic activity whereas Transdermal administration is a non-parenteral mode of drug uptake.
7. What do you mean by persorption in protein drug delivery system?
a) The passage of peptide molecules via porous membranes such as gastrointestinal tracts
b) Regulation of protein drug molecules through disulfide exchange
c) Penetration of liquids into less porous solid surface
d) Reabsorption of drug molecules through disulfide exchange
View Answer
Explanation: Persorption, by definition, is the penetration of liquid molecules into porous solid membranes. Hence in protein drug delivery system, it denotes the passaging of peptide molecules via porous solid membranes such as GI tract.
8. Only lipid soluble substances can move across the Blood Brain Barrier (BBB).
a) True
b) False
View Answer
Explanation: Even though BBB is a selective membrane, it can easily facilitate the movement of water and certain gases such as oxygen along with lipid soluble substances. Other necessary sugar molecules such as glucose require some work to pass through.
9. The Intestinal Epithelial Barrier (IEB) mediates which of the following process?
a) Cell necrosis
b) Synaptic connections
c) Embryonic induction
d) Homeostasis
View Answer
Explanation: The intestinal cells present in the IEB plays a crucial role in maintaining the Intestinal or Gut Homeostasis by the dissociation of host immune cells from other living cells such as symbiotic microorganisms.
10. Which type of cellular transport enables the entry of drugs through Blood Brain Barrier?
a) Transmembrane Diffusion
b) Exocytosis
c) Endocytosis
d) Osmosis
View Answer
Explanation: Transmembrane Diffusion, also known as Facilitated Diffusion, enables the movement of drug molecules from higher to lower concentrations once after the binding of protein drug molecules with specific carriers takes place.
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