Drug Biotechnology Questions and Answers – Drugs Excretion – Clearance Concept

This set of Drug Biotechnology Multiple Choice Questions & Answers (MCQs) focuses on “Drugs Excretion – Clearance Concept”.

1. What is total systemic clearance?
a) Sum of clearance from kidney
b) Sum of clearance from kidney and liver
c) Sum of clearance form non-renal clearances
d) Sum of renal and non-renal clearances
View Answer

Answer: d
Explanation: The sum of individual clearances by all eliminating organs is called total body clearance or total systemic clearance. It is expressed as the sum of renal and non-renal clearance. This term is applied to all organs involved in drug elimination.

2. What is the equation for clearance?
a) Elimination rate / plasma drug concentration
b) Plasma drug concentration/elimination rate
c) 1 / Plasma drug concentration
d) 1 / Elimination rate
View Answer

Answer: a
Explanation: Clearance is the hypothetical volume of body fluids containing drug from which the drug will be cleared completely in a specific period of time. It is expressed in ml/min. Clearance is expressed through the equation of elimination rate/plasma drug concentration.

3. What will be the elimination rate if the clearance is 130ml/min and drug concentration is 0.8 g/ml?
a) 104g/min
b) 140g/min
c) 130g/min
d) 100g/min
View Answer

Answer: a
Explanation: Clearance is expressed through the equation of elimination rate/plasma drug concentration. So, for the elimination rate, the equation becomes clearance * plasma drug concentration. Thus the answer becomes 130*0.8= 104 g/min.
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4. What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drug concentration is 4.2 ng/ml?
a) 148.80ml2/ng min
b) 150ml2/ng min
c) 152ml2/ng min
d) 140ml2/ng min
View Answer

Answer: a
Explanation: Renal clearance is defined as the volume of blood which is completely cleared of the unchanged drug by the kidney. It is expressed as the rate of urinary excretion/plasma drug concentration. Thus the answer is 625/4.2 = 148.80 ml2/ng min.

5. How renal clearance ratio is expressed?
a) Renal clearance of creatinine / renal clearance of the drug
b) 1/renal clearance of the drug
c) Renal clearance of drug/ renal clearance of creatinine
d) 1/renal clearance of creatinine
View Answer

Answer: c
Explanation: It is the clearance ratio of a drug with that of the clearance value compound which gets cleared by glomerular filtration only. Thus, the renal clearance ratio is expressed by clearance of drug/clearance of creatinine.
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6. What will be the renal clearance ratio of a drug whose renal clearance is 40ml/min and the clearance of creatinine is 95ml/min?
a) 0.421
b) 2.38
c) 0.010
d) 0.025
View Answer

Answer: a
Explanation: Renal clearance ratio is the ratio between renal clearance of the drug and the renal clearance value compound which gets cleared by glomerular filtration only. Thus, the answer is 40/95=0.421.

7. How do you calculate the rate of excretion by kidneys?
a) Rate of filtration – the rate of secretion – Rate of absorption
b) Rate of filtration + rate of secretion – Rate of absorption
c) Rate of filtration + rate of secretion + Rate of absorption
d) Rate of filtration – the rate of secretion + Rate of absorption
View Answer

Answer: b
Explanation: The rate of excretion through the kidneys is given by Rate of filtration + rate of secretion – Rate of absorption. Absorption is the reabsorption of the drug particles back to the system thus it gets minus from the filtrated amount and secreted amount.
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8. What will be the rate of filtration if the rate of secretion is 0.9 ml/ sec, rate of reabsorption is 0.2 ml/sec and the rate of excretion is 2ml/sec for a particular drug?
a) 3ml/sec
b) 0.3ml/sec
c) 1ml/sec
d) 1.3ml/sec
View Answer

Answer: d
Explanation: The rate of excretion through the kidneys is given by the Rate of filtration + rate of secretion – Rate of absorption. Thus, for the rate of filtration, the equation becomes Rate of excretion – the rate of secretion + rate of absorption.

Sanfoundry Global Education & Learning Series – Drug and Pharmaceutical Biotechnology.

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To practice all areas of Drug and Pharmaceutical Biotechnology, here is complete set of 1000+ Multiple Choice Questions and Answers.

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Manish Bhojasia - Founder & CTO at Sanfoundry
Manish Bhojasia, a technology veteran with 20+ years @ Cisco & Wipro, is Founder and CTO at Sanfoundry. He lives in Bangalore, and focuses on development of Linux Kernel, SAN Technologies, Advanced C, Data Structures & Alogrithms. Stay connected with him at LinkedIn.

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