This set of Tissue Engineering Multiple Choice Questions & Answers (MCQs) focuses on “Biomaterial -Tissue Interactions”.
1. What is the first step in Biomaterial-tissue interactions?
a) Cell Migration
b) Adsorption of proteins
c) Cell Development
d) Cell adhesion
Explanation: The initial phase in biomaterial–tissue connection is the underlying adsorption of proteins onto the outside of the biomaterial, which, in a mix with the physical and multiple properties of the surface, is thought to prompt ensuing cell practices, for example, bond, spreading and expansion.
2. The biomaterials are expected to mimic the functions of ____________
a) Extracellular Matrix (ECM)
b) Transmembrane proteins
d) Cell Organelles
Explanation: TE depends on platform biomaterials that will have cells from the body and, with the assistance of development factors or a bioreactor, will ideally prompt tissue regeneration. These biomaterials are subsequently expected to mirror the ECM capacities and connections with the cells and the encompassing tissues. These connections have now moved past a straightforward association with the organic frameworks to impact the natural procedures that can prompt tissue recovery.
3. _____________ is the first process involved in Biomaterial-Tissue interaction.
a) Foreign Body Response
Explanation: All in all, the nature of the cooperation among biomaterials and tissues in the body can be portrayed by two primary procedures. The foreign body response (FBR), is particularly activated on account of an implantable gadget so as to shield the body from the remote material. Once the biomaterial gadget or platform is embedded in the body, a tissue/biomaterial interface straightforwardly structures and causes a progression of incendiary reactions.
4. There is the formation of the fibrous capsule when the Biomaterial-Tissue implant is implanted in the body.
Explanation: Foreign body reaction (FBR) begins with an intense stage that can last as long as a few days. During this stage, leukocytes are actuated to the implantation site, and some development elements and cytokines are created. Monocytes are likewise enrolled, which separate into macrophages. After this period, which is the situation when the biomaterial is embedded in the body, an unending outside body response is activated. This is when lymphocytes and macrophages show up, notwithstanding the advancement of veins that are essential for wound mending and tissue recovery.
5. ____________ is one of the most important aspects of biomaterial-tissue interactions.
Explanation: Biomaterials should be able to mimic the native cell microenvironment and to control the spatiotemporal secretion of growth factors and morphogens.
6. There are three major types of biomaterial-tissue interactions.
Explanation: There are two major types of biomaterial-tissue interactions, namely local and systemic interactions. The local interactions are the ones taking place at the implant site, e.g., inflammation, infection, tumorigenesis, etc. Systemic interactions affect the organism as a whole triggering immune responses. These two usually are the reasons for the device associated complications like biomaterial’s failure.
7. Scaffolds acquire stability and strength from the cells.
Explanation: The scaffolds provide mechanical integrity and stability, the adhesive substrate, and soluble factors for the cells in newly formed tissues.
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