This set of Tissue Engineering Multiple Choice Questions & Answers (MCQs) focuses on “Synthetic Biomaterials”.
1. Poly (N-isopropyl acrylamide) (PNIPAAm) is used in ________________
c) RNA silencing
Explanation: A principle preferred position of utilizing PNIPAAm for cell-embodiment and cell-treatment applications is that one can without much of a stretch epitomize the cells in PNIPAAm at room temperature and afterward structure the gel after expanding the temperature. The body temperature is higher than the temperature required for gel development. Hence, the cells inside the PNIPAAm can undoubtedly be infused into the body for regenerative purposes.
2. Which of the following properties of Poly (N-isopropyl acrylamide) (PNIPAAm) is an advantage in tissue regeneration?
Explanation: The unique temperature-dependent gelation of PNIPAAm polymers is of great advantage for cell culture and tissue regeneration.
3. _____________ is synthesized by the copolymerization of cyclic dimers of glycolic and lactic acids.
a) Poly (lactic acid-co-glycolic acid)
b) Poly (glycolic acid)
c) Poly (lactic acid)
Explanation: Poly (lactic acid co-glycolic corrosive) (PLGA) is incorporated by the copolymerization of cyclic dimers of glycolic and lactic acids. It is FDA- affirmed biopolymer and has broadly been utilized in TE and drug conveyance applications on account of its biocompatibility, biodegradability, and tunable mechanical properties.
4. Dermagraft is a Poly (lactic acid-co-glycolic acid) – based skin product available commercially.
Explanation: PLGA has been used for skin TE for a very long time. Dermagraft is a commercially available skin tissue, which includes bioresorbable PLGA (i.e., polyglactin 910).
5. It is hard to degrade Poly (ε-caprolactone) (PCL) than PGA and PLGA.
Explanation: PLC’s degradation rate is less than that of PGA and PLGA because of five hydrophobic —CH2 moieties in its polymer chain.
6. Poly (ε-caprolactone) (PCL) is usually in non-permanent scaffolds.
Explanation: The scaffolds used with PCL are generally nonpermanent and degrade over time to be replaced by natural ECM of new tissue.
7. _____________ is a synthetic and hydrophilic polymer.
a) PEG or poly (ethylene oxide)
Explanation: PEG or poly (ethylene oxide) is a synthetic and hydrophilic polymer with the formula of OH–(CH2CH2O)n–CH2CH2OH. PEG is an FDA-approved polymer with wide biomedical applications because of its biocompatibility and low toxicity.
8. Poly (vinyl alcohol) (PVA) is a derivative of __________
a) Poly (vinyl acetate)
c) Poly (lactic acid)
Explanation: Poly (vinyl alcohol) (PVA) can be synthesized from poly (vinyl acetate) through hydrolysis, alcoholysis, or aminolysis.
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