This set of Immunology Multiple Choice Questions & Answers (MCQs) focuses on “Cytokine Antagonists, Cytokine related Diseases and Cytokine based Therapies”.
1. Which of the following are released during bacterial septic shock?
a) Chemokines
b) Exotoxins
c) Endotoxins
d) A – B toxins
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Explanation: Bacterial septic shock is because of the infection caused due to gram negative bacteria. Gram negative bacteria releases endotoxins.
2. Which of the following are released in higher amounts during bacterial septic shock?
a) IL – 2 and TNF – β
b) IL – 4 and IFN – α
c) IL – 4 and TNF – α
d) IL – 2 and IFN – δ
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Explanation: During bacterial septic shock, due to the binding of endotoxins to TLRs (Toll Like Receptors) on DCs and macrophages, higher amounts of IL – 4 and TNF – α are released.
3. To which of the following, does the endotoxin bind during bacterial septic shock?
a) Dendritic cells
b) Macrophages
c) T cells
d) Both dendritic cells and macrophages
View Answer
Explanation: When gram negative bacteria infects the body, certain endotoxins are released. These endotoxins bind to the TLRs of dendritic cells and macrophages.
4. Which of the following cytokine related diseases is caused because of superantigens?
a) Bacterial septic shock
b) Bacterial toxic shock
c) Chagas disease
d) Induction of Cancer
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Explanation: Bacterial toxic shock is caused due to the superantigens. Superantigens are those which bind to class II MHC and Vβ domain of TCR simultaneously
5. Cytokines can induce cancer. True/False?
a) True
b) False
View Answer
Explanation: Cytokines can absolutely induce cancer. One such cancerous cell is the cervical bladder cancer cell which secretes high amounts of interleukin – 6.
6. Which of the following interleukines is released due to cervical bladder cancer cell?
a) Interleukin – 3
b) Interleukin – 4
c) Interleukin – 5
d) Interleukin – 6
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Explanation: Interleukin – 6 or IL – 6 is released in high amounts due to the cervical bladder cancer cell. Cervical bladder cancer is a cytokine related disease.
7. Which of the following cytokine related diseases is caused because of protozoan infection?
a) Bacterial septic shock
b) Bacterial toxic shock
c) Chagas disease
d) Induction of Cancer
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Explanation: Chagas disease is a cytokine related disease. This is because of the infection caused by a protozoan called Trypanosoma Cruzi. It leads to immune suppression.
8. Which of the following marker’s expression is decreased in a person infected by chagas disease?
a) CD28
b) CD4
c) CD8
d) CD25
View Answer
Explanation: The expression of CD25 is decreased in a person infected with chagas disease. This is due to the immune suppression, i.e., no activation of T cells.
9. Which of the following subunits are expressed when IL – 2R has low affinity?
a) α
b) β
c) γ
d) α, β, γ
View Answer
Explanation: Interleukin – 2 receptor or IL – 2R is the well studied interleukin receptor. When the affinity of IL – 2R is low, it expresses only α subunit.
10. Which of the following subunits are expressed when IL – 2R has intermediate affinity?
a) α, β
b) β, γ
c) γ, α
d) α, β, γ
View Answer
Explanation: Interleukin – 2 receptor or IL – 2R is the well studied interleukin receptor. When the affinity of IL – 2R is intermediate, it expresses both α and β subunits.
11. Which of the following subunits are expressed when IL – 2R has high affinity?
a) α, β
b) β
c) γ
d) α, β, γ
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Explanation: Interleukin – 2 receptor or IL – 2R has three subunits α(CD25), β(CD122) and γ(CD132). When the affinity of IL – 2R is high, it expresses all the three subunits, i.e., α, β and γ.
12. Cytokine analogs are used in cytokine based therapies. True/False?
a) True
b) False
View Answer
Explanation: Cytokine based therapies are implemented in order to fight against the diseases caused due to the upregulation or downregulation of cytokines. Usage of cytokine analogs is one of them. Cytokine analogs are those which are similar in structure but different in function to cytokines.
Sanfoundry Global Education & Learning Series – Immunology.
To practice all areas of Immunology, here is complete set of 1000+ Multiple Choice Questions and Answers.
