Cytokines & Chemokines Questions and Answers

This set of Immunology Multiple Choice Questions & Answers (MCQs) focuses on “General Properties of Cytokines and Chemokines”.

1. Which of the following cytokines helps in terminating inflammatory responses?
a) TGF-beta
b) IL-2
c) IL-3
d) INF-alpha
View Answer

Answer: a
Explanation: TGF-beta, Transforming growth factor beta is a polypeptide, superfamily of cytokines. The major function of TGF-beta is to regulate and control the proliferations and differentiations of many immuno cells in the body. Thus, terminating the inflammations and apoptosis.

2. Which of the following interleukin is responsible for T cell expansion after antigen recognition?
a) IL-3
b) IL-2
c) IL-7
d) IL-1
View Answer

Answer: b
Explanation: Interleukin 2 or IL-2 is a cytokine that is secreted by activated CD4⁺ cells and expressed by CD8⁺ cells. The main function of this is to regulate the activities of all T cells.

3. ________are responsible for recruiting immune cells to a specific location within the body.
a) Interferons
b) Interleukins
c) Chemokines
d) TNFs
View Answer

Answer: c
Explanation: Chemokines are one of the superfamily of cytokines. These work through the Chemotaxis process, hence the name Chemokines. These are responsible for recruiting immune cells to the particular target cells.

4. Cytokine that can affect the function of many cells or is involved with many target cells is called a _______cytokine.
a) Redundant
b) Synergic
c) Antagonistic
d) Pleiotropic
View Answer

Answer: d
Explanation: Pleiotropic cytokines are the cytokines which shows multiple functions. The same cytokine can activate a T cell, can proliferate it and also can differentiate it. Meanwhile it can act on whole other type of cell too.

5. What is that property of cytokines called where two or more cytokines act together on a single target cell?
a) Redundancy
b) Synergy
c) Antogonism
d) Pleiotropy
View Answer

Answer: a
Explanation: Redundancy is one of the properties of Cytokines. Here, multiple cytokines come together and performs the function on a single target cell. For example, IL-2, IL-4 and IL-5 together helping in activating, proliferating and differentiating.

6. What determines a particular cell should be activated or not?
a) Absence of cytokine receptor
b) Presence if cytokine receptor
c) Cytokine receptor differentiation
d) Doesn’t need a cytokine at all
View Answer

Answer: b
Explanation: All the immune cells secret cytokines. In order to perform it’s function the target must have the corresponding cytokine receptor. The interaction between these two produces one of the many signals that occur during the signal transduction.

7. IL-2, IL-3, GM-CSF are the representatives of which cytokine family?
a) Interleukin family
b) Interferon family
c) Hematopoietic family
d) Chemokine family
View Answer

Answer: c
Explanation: The above mentioned cytokines are the representatives of Hematopoietic cytokine family. They help in the signal transduction and the regulation of proliferation and differentiation of blood cells.

8. Which family of the cytokines use the JAk kinase for expression?
a) Interferon family
b) Chemokine family
c) Hematopoietic family
d) Interleukin family
View Answer

Answer: d
Explanation: JAK kinases are often the sites of viral entries. These undergo particular signalling steps and the interleukin is released or expressed corresponding to the target cell.

9. Which of the following cytokine families regulate target cell’s development and death?
a) Tumour Necrosis Factor family
b) Interleukin family
c) Interferon family
d) Hematopoietic family
View Answer

Answer: a
Explanation: Tumour Necrosis Factor family can induce the fever, apoptotic cell deaths and sometimes inflammatory responses too.

10. Which proteins inhibit the activity of the cytokines?
a) Synergic cytokines
b) Antagonistic cytokines
c) Redundant cytokinea
d) Chemokines
View Answer

Answer: b
Explanation: Antagonistic cytokines or proteins are those which inhibits the activity of the other cytokines. For example, IFN-gamma blocks the class switching process by inhibiting the activity of IL-4.

11. IFN-gamma activating macrophage which will release IL-12. This IL-12 activates TH cells which will secrete IL-2, IL-4, IL-5 is an example of _______
a) Synergy
b) Anatgonism
c) Cascade insuction
d) Redundancy
View Answer

Answer: c
Explanation: The above described pathway is an example of cascade induction. Cascade Induction is the process where the activity of one cytokine results in either secretion or activity of the other cytokines.

12. Cytokines can induce cancer.
a) False
b) True
View Answer

Answer: b
Explanation: Cytokines can induce cancer. The cervical bladder cancer cell secretes high amounts of Interleukin-6 and Interleukin-alpha.

More MCQs on Cytokines and Chemokines:

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