This set of Immunology Multiple Choice Questions & Answers (MCQs) focuses on “B-Cell Receptor and T-Cell Receptor Expression”.
1. A B cell activates by its first encounter with an antigen called _______ antigen.
a) First
b) Cognate
c) Hanging
d) Unconnected
View Answer
Explanation: A cognate antigen is the antigen because of which a B cell gets activated in its first encounter. Once it encounters, it receives signal from a T cell and differentiates into effector cells and memory cells.
2. Which of the following is included in B Cell Receptor?
a) CD24
b) CD59
c) CD79
d) CD16
View Answer
Explanation: A B cell receptor includes both of the two, a cluster differentiation marker, CD79 and an immunoglobulin. It is extended out of the membrane too. CD79 helps in detecting the neoplasms of B cell.
3. What are the chains present in a Pre-BCR?
a) One light chain and one heavy chain
b) One surrogate light chain and one heavy chain
c) Two light chains and Two heavy chains
d) Two surrogate light chains and two heavy chains
View Answer
Explanation: A pre-BCR, also known as Precursor-B cell, has two surrogate light chains and two heavy chains as a part of signal transduction process. These surrogate chains give the confirmation that heavy chains have been rearranged.
4. In a matured B cell, which of the following signalling molecules are also present?
a) Ig-alpha and Ig-beta
b) Ig-alpha and Ig-gamma
c) Ig-beta and Ig-gamma
d) Ig-gamma and Ig-delta
View Answer
Explanation: One must not get confused with the signalling molecules Ig-alpha and Ig-beta to the immunoglobulins. IgA is different from Ig-alpha. These are called the heterodimer subunits.
5. The immunoglobulin isotype and the signal transduction region in a BCR are connected by _______
a) Covalent bonds
b) Ionic bonds
c) Disulphide bonds
d) Hydrogen bonds
View Answer
Explanation: In a B cell receptor, the membrane bound immunoglobulin part and the region that is responsible for signal transduction are connected by disulphide bonds, hence them interacting strongly with high affinity.
6. Which of the following is replaced by the heterodimer subunits?
a) mIgG
b) mIgM
c) mIgA
d) mIgD
View Answer
Explanation: Heterodimer subunits have the capability of replacing mIgM because they can exist as an association with other pre-b cell specific proteins. The structure of the B cell is defined by this replacement.
7. The J segment and the D segment of heavy chains are recombined in ____________
a) Pro-B cells
b) Late pro-B cells
c) Pre-B cells
d) Mature B cells
View Answer
Explanation: The J and D segments of the heavy chains of an immunoglobulin are recombined in pro-B cells using RAG 1 and RAG 2 enzymes, where RAG 1 and RAG 2 are recombination activating proteins.
8. The V and DJ recombination takes place in which stage of B cell expression?
a) Pro-B cells
b) Late pro-B cells
c) Pre-B cells
d) Mature B cells
View Answer
Explanation: After the recombination of DJ segments, the pro-B cell now becomes the late pro-B cell where the V segment of the heavy chain recombines with the DJ segments.
9. The B cell receptor is involved with various BCR derived lymphoid cancers. True/False?
a) True
b) False
View Answer
Explanation: Due to the uncontrolled proliferation of B cells and in turn BCRs, many of the B cell derived lymphoid cancers have been observed. This is a caused due to the extrinsic and intrinsic mechanisms of BCR.
10. Which of the following interleukins help in proliferation of activated B cells?
a) IL-2
b) IL-3
c) IL-4
d) IL-5
View Answer
Explanation: Among any of the things that help in activating, proliferating and differentiating B cells by getting recognized by BCRs, interleukin 2 is one of them. It also helps in reducing the accumulation of BCRs in the body
Sanfoundry Global Education & Learning Series – Immunology.
To practice all areas of Immunology, here is complete set of 1000+ Multiple Choice Questions and Answers.
If you find a mistake in question / option / answer, kindly take a screenshot and email to [email protected]
