This set of Immunology Multiple Choice Questions & Answers (MCQs) focuses on “Immune System Cells – Lymphoid Lineage”.
1. Which of the following is NOT a cell type of the lymphoid lineage?
a) Natural Killer Cells
b) T Cells
c) Macrophages
d) B cells
View Answer
Explanation: From the lymphoid lineage, three cell types are generated namely B cell, T cell and Natural Killer Cells. Macrophages are the cells of myeloid lineage.
2. The surface marker present on Natural Killer Cells is _______
a) NK 1.1
b) NK 1.5
c) NK 3.2
d) NK 2.1
View Answer
Explanation: Natural Killer Cells have specialized surface markers namely NK 1.1 on their cell surface which distinguish them from rest of the immune cells. Along with the NK 1.1 markers, NK cells have some cytotoxic granules on their surface.
3. Full form of CD is ____________
a) Cells of Designation
b) Cluster of Differentiation
c) Cluster of Design
d) Cells of Division
View Answer
Explanation: CD is a surface marker found on the cells of immune system. Its full form is Cluster of Differentiation. However, it is also known as Cluster of Designation.
4. Which of the CD markers is not present on a Cytotoxic T cell?
a) CD5
b) CD4
c) CD8
d) CD2
View Answer
Explanation: The surface markers of Cytotoxic T cells include CD2, CD3, CD5, CD8, CD28 and CD45. CD4 is a specialized marker for Helper T cells.
5. State true or false.
The antigen specific receptors on the surface of any immune cell are identical to each other.
a) True
b) False
View Answer
Explanation: The antigen specific receptors such as B cell receptor and T cell receptor are diverse on different cells but an individual cell carries identical receptors. Hence, the statement is true.
6. What is the site of maturation of B lymphocytes?
a) Lymph nodes
b) Spleen
c) Thymus
d) Bursa of Fabricius
View Answer
Explanation: B cells mature at the bursa of Fabricius in birds and hence they got their name ‘B’ cells. However, in mammals and mice, the site of maturation of B cells in Bone marrow.
7. The process by which B cells become more capable of binding to an antigen is called as ___________
a) Class switching
b) Somatic hypermutation
c) Conjugation
d) Recombination
View Answer
Explanation: Somatic hypermutation is the cellular process of immune system that adapts to the new immunogens encountered by the antibodies. It takes place by point mutations in the V-regions of heavy and light chain of immunoglobulins.
8. Which of these cells give rise to antibodies?
a) B cells
b) Plasma cells
c) Lymphocytes
d) T cells
View Answer
Explanation: Upon maturation and activation, B cells differentiate into Plasma cells which give rise to Antibodies. It is to be noted that B cells do not directly give rise to the antibodies. Lymphocytes, however, is a lineage of cells which gives rise to B cells and T cells.
9. Where do the T cells mature?
a) Thymus
b) Bone marrow
c) Lymph nodes
d) Spleen
View Answer
Explanation: Thymus is the site of maturation of T cells. In spite of being born into Bone marrow, they mature into Thymus and that is why they got the name ‘T’ cells.
10. What is the ratio of CD4+ cells to CD8+ cells?
a) 1:2
b) 2:5
c) 2:1
d) 1:5
View Answer
Explanation: The CD4+ cells are Helper T cells and CD8+ cells are the Cytotoxic T cells. Both of these cells are present in the ratio of 2:1.
11. Which of the following cell types regulate the immune response against the intracellular pathogens?
a) Cytotoxic T cells
b) Type 1 Helper T cells
c) Type 2 Helper T cells
d) B cells
View Answer
Explanation: The immune response to intracellular pathogens is regulated by the Type 1 Helper T cells whereas Type 2 Helper T cells regulate the immune response against extracellular pathogens.
12. Which of the following is not a subtype of Helper T cells?
a) TH1
b) TH17
c) TFH
d) TSH
View Answer
Explanation: The subtypes of the Helper T cells are TH1, TH2, TH17 and TFH. TSH is not a type of Helper T cells.
13. How do Natural Killer Cells recognize and kill the abnormal cells?
a) By presence of MHC class I
b) By absence of MHC class I
c) By presence of MHC class II
d) By presence of MHC class II
View Answer
Explanation: MHC class I molecules are expressed by all the normal cells but not expressed by some tumor cells and virus infected cells. These are the cells that are killed by the Natural Killer Cells.
14. State true or false.
NKT cells belong to myeloid lineage.
a) True
b) False
View Answer
Explanation: NKT cells are the cells of lymphoid lineage which have features of both T cells and Natural Killer Cells. Therefore, the given statement is false.
15. Which of the following surface marker is a characteristic of Helper T cells?
a) CD8
b) CD3
c) CD2
d) CD4
View Answer
Explanation: The Helper T cells contain the surface marker CD4 which is absent in all other cells of the lymphoid cells. Hence, CD4 marker acts as a characteristic of Helper T cells.
Sanfoundry Global Education & Learning Series – Immunology.
To practice all areas of Immunology, here is complete set of 1000+ Multiple Choice Questions and Answers.
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