This set of Immunology Multiple Choice Questions & Answers (MCQs) focuses on “Structure of Antibodies”.
1. Antibodies are __________
a) Proteins
b) Lipids
c) Fats
d) Glycoproteins
View Answer
Explanation: Antibodies are glycoproteins. Glycoproteins are those which have a carbohydrate group attached to the polypeptide chain. These are produced by plasma cells. Plasma cells are B-effector cells.
2. What’s the bond that is present between light chains and heavy chains?
a) Covalent
b) Hydrogen
c) Di-sulphide
d) Ionic
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Explanation: The light chains and the heavy chains of an antibody are strongly bound by Di-sulphide bonds. There are three di-sulphide bonds on the whole.
3. What is the antigen binding site on an antibody called?
a) Paratope
b) Epitope
c) Allotype
d) Ideotype
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Explanation: The antigen binding site on an antibody is called paratope. Epitope is present on Antigen. Allotype, Isotype and Idiotype are the classifications of antibodies.
4. The hypervariable region resides in the ________
a) C terminal of light chain
b) N terminal of heavy chain
c) C terminal of heavy chain and light chain
d) N terminal of heavy chain and light chain
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Explanation: The hypervariable region resides in the N terminal region of both light chain and heavy chain. In the C terminal region, constant regions are found.
5. Where are the CDRs present in an antibody?
a) Constant region of heavy chain and Constant region of light chain
b) Constant region of heavy chain and Variable region of light chain
c) Variable region of heavy chain and Variable region of light chain
d) Variable region of heavy chain and Constant region of light chain
View Answer
Explanation: An antibody contains 12 CDRs on the whole. The variable region of the heavy chain has 6 CDRs and the variable region of light chain has 6 CDRs.
6. Fab and Fc domains are formed when an antibody is digested with _________
a) Pepsin
b) Papain
c) Tripsin
d) Pectin
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Explanation: Papain is a cysteine protease. It cleaves an antibody into three fragments. Two Fab (Fragnent antigen binding) domains and one Fc (Fragmant crystallizable) domain.
7. Fab region is involved in which of the following function?
a) Complement pathway activation
b) Determining the receptors
c) Degrade the antigen
d) Bind to the antigen
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Explanation: Fab – Fragment antigen binding region binds has the hypervariable region that binds to the antigen. CDRs are present in Fab region.
8. What are the types of light chains a plasma cell can produce in an antibody?
a) Kappa and Lambda
b) Kappa and Gamma
c) Gamma and Lambda
d) Gamma and Delta
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Explanation: There are two types of light chains, kappa chain and lambda chain. An antibody will have any one of the two. The difference in the chains arises during the rearrangement of gene segments.
9. Hinge regions provides______
a) CDRs
b) Flexibility
c) Solubility process
d) Complement proteins
View Answer
Explanation: Hinge regions in antibodies provide flexibility to them. These are present in between the constant region of the heavy chain. Not all antibodies have the hinge region.
10. Which of the following amino acids are mainly found in the hinge region?
a) Proline and Cysteine
b) Proline and Threonine
c) Proline and Isoproline
d) Proline and Valine
View Answer
Explanation: The hinge region of any antibody has two amino acids, proline and cysteine. These are responsible for the flexibility of the antibody. These hinge regions are present in the heavy chain.
Sanfoundry Global Education & Learning Series – Immunology.
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