This set of Immunology Multiple Choice Questions & Answers (MCQs) focuses on “Six Families of Cytokines and Associated Receptor Molecules”.
1. Which of these cytokine families is responsible for inflammation?
a) Chemokine
b) Interferon
c) Interleukins
d) Hematopoietic
View Answer
Explanation: Chemokines are the family of cytokines which are responsible for inflammation. They recruit monocytes, neutrophils and all other types of the effector cells to the site of tissue damage.
2. Which of these family of cytokines are involved in the immunotherapy for RA (rheumatoid arthritis)?
a) Interleukin
b) Interferon
c) Chemokine
d) Hematopoietic
View Answer
Explanation: Interferon are involved with treating rheumatoid arthritis. This is also known as interferon therapy, mostly for autoimmune diseases.
3. Which of the following cytokine family is released in response to a virus infection?
a) Interleukins
b) Hematopoietic
c) Interferons
d) Chemokines
View Answer
Explanation: Interferons are the family if cytokines which are released in response to virus infection. These are meant to increase the anti-viral responses or defenses of the virus-infected cells.
4. IL-1 to IL-29 belongs to _________ family of cytokines.
a) Interferon
b) Chemokine
c) Tumour Necrosis factors
d) Hematopoietic
View Answer
Explanation: Hematopoietic family of cytokines comprise of many cytokines and interleukins. IL-1 to IL-29 belong to this family along with others like GM-CSFs. They help in regulating the proliferation and differentiation of the blood cells.
5. What is Janus Kinase?
a) Transduces cytokine-mediated signals
b) Inhibits cytokine-mediated signals
c) Regulates cytokine-mediated signals
d) Expressed because of cytokine-mediated signals
View Answer
Explanation: JAK or Janus Kinase is a phosphorylating kinase. This transduce the cytokine-mediated signals in the JAK-STAT cytokine signalling pathway.
6. What is STAT?
a) Belongs to cytokine family
b) Transcription protein involved in JAK-STAT pathway
c) Regulating protein
c) Inhibits transcription
View Answer
Explanation: STAT is the transcription protein involved in JAK-STAT cytokine signalling pathway. These get phosphorylated by JAK and initiate the transcription process.
7. After the phosphorylation of STAT, what state does it turn into?
a) Polymerises
b) Trimerizes
c) Dimerises
d) Stays the same
View Answer
Explanation: STAT gets phosphorylated by JAK, it gets separated from the receptor subunits. After the separation, dimerization of the STAT occurs.
8. What makes a macrophage release or express IL-12?
a) When it is infected
b) When it is overloaded with IL-12
c) When apoptosis is about t occur
d) When dimerised STAT binds to it
View Answer
Explanation: When dimerised STAT binds to any cell, corresponding cytokines are expressed. If the target cell is macrophage, IL-12 is expressed.
9. Which of the following receptors is a part of JAK- STAT pathway?
a) IFN-gamma receptor
b) IFN-alpha receptor
c) IL-2 receptor
d) IL-3 receptor
View Answer
Explanation: IFN-gamma is involved with the JAK – STAT signalling pathway. Through this pathway, IFN-gamma triggers antiviral and adaptive immune responses.
10. JAK is a________
a) Cysteine residue
b) Tyrosine residue
c) Serine residue
d) Valine residue
View Answer
Explanation: JAK or Janus Kinase is a tyrosine residue which can transduce the cytokine-mediated signalling pathway. These signals are transduced via JAK-STAT pathway.
Sanfoundry Global Education & Learning Series – Immunology.
To practice all areas of Immunology, here is complete set of 1000+ Multiple Choice Questions and Answers.
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