This set of Immunology Multiple Choice Questions & Answers (MCQs) focuses on “Signal Transduction in B-Cells”.
1. What are the types of B Cell activations?
a) Thymus dependent and Thymus independent
b) IgM dependent and IgM independent
c) IgD dependent and IgD independent
d) IgM dependent and IgD independent
View Answer
Explanation: There are two ways by which a B cell gets activated. One is thymus dependent (TD) and the other is thymus independent (TD). When a pathogen is in the vicinity of B cell, the cell is activated by one of the either pathway.
2. When does a B cell gets activated?
a) When an antibody is present
b) When an antigen is present
c) When a thymocute is present
d) When a macrophage is present
View Answer
Explanation: A B cell gets activated when an antigen is present in its vicinity. The minute it is activated, it differentiates into memory cells and plasma cells.
3. Which of the following technique involves B cell proliferations?
a) Carcoma
b) Carcinoma
c) Hybridoma
d) Necrosis
View Answer
Explanation: Hybridoma is the process everyone use which involves B cell proliferations. This method is used to produce monoclonal antibodies.
4. Which receptor is mainly responsible for the signal transduction in B cell?
a) CD25
b) CD19
c) CD4
d) CD8
View Answer
Explanation: CD19 along with the other minor CDs is responsible for identifying and transducing the signal against an antigen in B cell. All the CDs are present in the membrane of the cell.
5. What is meant by thymus dependent B cell activation?
a) Activation process is carried out in the thymus
b) Only thymocytes are involved in the process
c) Interaction with T helper cells is required
d) Interaction with T cytotoxic cells is required
View Answer
Explanation: In the thymus dependent process, the B cells need to interact with the T helper cells for them to activate. Upon activation they proliferate and differentiate into memory cells and effector cells.
6. What is meant by thymus independent B cell activation?
a) The activation process is carried out in the thymus
b) Interaction with T cells is not necessary
c) Interaction with T cells is required
d) Only the differentiation is occurred in the thymus
View Answer
Explanation: In the thymus independent B cell activation proceas, the B cell won’t interact with any type of T cells. The antigen itself activates the B cells in two different ways based on its nature.
7. What is the medium used for the Hybridoma technology?
a) HAT
b) PAT
c) HET
d) PUT
View Answer
Explanation: The medium used in the Hybridoma proceas is called the HAT media. The hybridomas are allowed to proliferate in this medium. It is a seclection medium.
8. When fusion of cells occur during the Hybridoma process, which of the combination survives?
a) B cell and B cell
b) B cell and T cell
c) Myeloma cell and Myeloma cell
d) Myeloma cell and B cell
View Answer
Explanation: During the hybridoma process, myeloma cell fused with B cell survives. This is because of the uncontrolled proliferation of myeloma cells. These cells are called hybridomas.
9. Which of the following interleukins is involved in signal transduction of B cells?
a) Interleukin-2
b) Interleukin-3
c) Interleukin-7
d) Interleukin-8
View Answer
Explanation: The proliferation of pro-B cells to pre-B cells is driven by Interleukin-7. This is secreted by bone marrow. IL-7 also helps in regulating the differentiation of B cells.
10. Along with IgM and IgD, __________ are also present on the surface of a matured B cell.
a) Ig-alpha and lg-beta
b) Ig-alpha and Ig-gamma
c) Ig-gamma and Ig-beta
d) Ig-beta and Ig-delta
View Answer
Explanation: Along with IgM and IgD, Ig-alpha and Ig-beta are present on the surface of a matured B cell. These are proteins which are non-covalently associated. These help in the expression and function of B cell antigen receptor.
11. As a part of signalling, during the B cell maturation process surrogate chain is formed. Which chain is that?
a) Heavy chains
b) Light chains
c) Both heavy chain and light chain
d) Neither light chain nor heavy chain
View Answer
Explanation: During the maturation process of B cell, a surrogate light chain is formed. The function of this light chain is auite unknown but many have predicted that it might be the part of cell signalling.
12. Because of which interaction from the following does the costimulatory signal arises?
a) CD40 and CD40L
b) B7 and CD28
c) CD19 and CD81
d) IL-7 and IL-7R
View Answer
Explanation: The costimulatory signal comes from the interaction between B7 and CD28. This particular signal is important for various reasons. It is necessary for full activation of B cells and helps in preventing apoptosis, in regulation of proliferation and differentiation and also for cell to cell cooperation.
Sanfoundry Global Education & Learning Series – Immunology.
To practice all areas of Immunology, here is complete set of 1000+ Multiple Choice Questions and Answers.
If you find a mistake in question / option / answer, kindly take a screenshot and email to [email protected]
