This set of Cell Biology Multiple Choice Questions & Answers (MCQs) focuses on “Combating Cancer”.
1. Which agents are used in passive immunotherapy of cancer?
Explanation: Passive or adoptive immunotherapy is the administration of antibodies that are specific to a type of cancer epitope. This allows the body to develop an immune response against the cancer.
2. Conventional therapies like chemosurgery kill a large number of healthy cells in addition to cancer cells.
Explanation: Conventional therapies of cancer such as surgery and chemotherapy are not successful in treating metastatic cancers. These therapies also target a large number of normal cells in addition to cancer cells.
3. Spontaneous remissions were studied by which of the following scientists?
a) Barbara McClintock
b) William Coley
c) Fredrick Sanger
d) James Watson
Explanation: The best studied cases of spontaneous remissions in cancer were recorded in the 1800s by a New York physician William Coley. He developed a bacterial extract which when injected could stimulate a person’s immunity.
4. Which of the following is a humanized antibody?
Explanation: Herceptin is the commercial name for the monoclonal antibody Trastuzumab. It is used as a passive immunotherapy drug for HER2 positive cancer cells.
5. Which drug was approved in 1997 for the treatment of non-Hodgkin’s B-cell lymphoma?
Explanation: Rituxan was approved in 1997 for the treatment of non-Hodgkin’s B-cell lymphoma. It binds to the cell-surface protein CD20 that is present on malignant B cells in 95 percent of cases of this disease.
6. The drug Vectibix is directed against _____________________
a) Her2 receptor
b) Her3 receptor
c) EGF receptor
Explanation: Vectibix is used in passive immunotherapy to target the epidermal growth factor receptor (EGF-receptor) present on the cell surface in cases of metastatic colon cancer. This drug needs to be administered once per week.
7. Adoptive immunotherapy involves the person’s own immune system for treatment against cancer.
Explanation: Active immunotherapy, also termed adoptive immunotherapy is aimed at involving the patient’s own immune system in the fight against cancer, rather than administering any foreign drugs.
8. Which immune cells are generally used in the treatment of cancer using adoptive immunotherapy?
a) Mast cells
b) Dendritic cells
c) Neuronal cells
d) Malignant cells
Explanation: Dendritic cells are typically used in adoptive immunotherapy. These cells are derived from the patient and stimulated in one or the other way in vitro and then reintroduced into the patient.
9. Which of the following disease is caused by a chromosomal translocation?
a) Chronic myelogenous leukemia
b) Hodgkin’s B-cell lymphoma
c) Alzheimer’s disease
d) Parkinson’s disease
Explanation: Chronic myelogenous leukemia is caused by a chromosomal translocation that brings together the proto-oncogene (ABL) in contact with another gene (BCR) to form a chimeric gene (BCR ABL).
10. Angiogenesis is the process of formation of __________________
a) cancer cells
b) blood vessels
d) immune cells
Explanation: Angiogenesis is the process of the formation of new blood vessels. When a tumor grows in size, its nutrient requirements and metabolism also increase and angiogenesis is initiated for its nourishment.
11. Cancer cells promote angiogenesis by secreting ________________________
c) growth factors
d) necrosis factors
Explanation: Cancer cells promote angiogenesis by secreting growth factors such as VEGF that act on the endothelial cells of surrounding blood vessels and stimulate them to proliferate and form new blood vessels.
12. Endostatin is a ___________________
a) angiogenesis inhibitor
b) angiogenesis promoter
c) transcription factor
d) cell surface receptor
Explanation: Endostatin is a naturally occurring inhibitor of angiogenesis – the process of formation of new blood vessels. It is a 20 kilo Dalton fragment of C-terminal of Collagen XVIII, which specifically inhibits the proliferation of endothelial cells.
Sanfoundry Global Education & Learning Series – Cell Biology.
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