Cell Biology Questions and Answers – Extracellular Matrix and Cell Interactions – Tight Junctions

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This set of Cell Biology Multiple Choice Questions & Answers (MCQs) focuses on “Extracellular Matrix and Cell Interactions – Tight Junctions”.

1. Which of the following contains tight junctions?
a) Chordates
b) Arthropods
c) Nematodes
d) Molluscs
View Answer

Answer: a
Explanation: Tight junctions are present only in vertebrates, otherwise known as chordates. The invertebrates contain a junction called septate junction.
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2. Which of the following is defined by the tight junctions?
a) Efficiency of drugs
b) Diffusion of drugs
c) Breakdown of drugs
d) Absorption of drugs
View Answer

Answer: b
Explanation: The tight junctions take care of the permeability of the molecules through the cells. Thus the tight junction is responsible for the diffusion of the drugs through the cells.

3. Which of the following protein is present in large amount in tight junctions?
a) Albumin
b) Globulin
c) Claudin
d) Elastin
View Answer

Answer: c
Explanation: The tight junctions contain the protein claudin in large amount followed by occluding and other proteins. The tight junctions are useful in the transport of materials.

4. The endocytosis happens in the apical surface and the exocytosis happens in the basolateral surface.
a) True
b) Fals
View Answer

Answer: a
Explanation: The apical surface which is exposed to the lumen helps in the transport of materials inside the cell. The basolateral surface which is at the sides of the helps in the transport of materials outside the cell.
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5. Leaky epithelium is present in bile ducts.
a) True
b) False
View Answer

Answer: b
Explanation: The leaky epithelium is the type of epithelium that is not present in bile ducts.

6. Which of the following is the first observed tight junction proteins?
a) Zonula occludens – 1
b) Zonula occludens – β
c) Zonula occludens – A
d) Zonula occludens – α
View Answer

Answer: a
Explanation: Zonula occludens – 1 was the first tight junction protein discovered in the year 1986, which is abbreviated as ZO-1. This has a molecular weight of 220kDa.

7. What is the radius of the tight junctions?
a) 3 Å
b) 4 Å
c) 5 Å
d) 6 Å
View Answer

Answer: b
Explanation: The radius of the tight junction depends on the permeability of the materials which has to pass through it. The claudin based pores have a radius of 4 Å. This may vary with different types of proteins.
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Manish Bhojasia, a technology veteran with 20+ years @ Cisco & Wipro, is Founder and CTO at Sanfoundry. He is Linux Kernel Developer & SAN Architect and is passionate about competency developments in these areas. He lives in Bangalore and delivers focused training sessions to IT professionals in Linux Kernel, Linux Debugging, Linux Device Drivers, Linux Networking, Linux Storage, Advanced C Programming, SAN Storage Technologies, SCSI Internals & Storage Protocols such as iSCSI & Fiber Channel. Stay connected with him @ LinkedIn