This set of Molecular Endocrinology Multiple Choice Questions & Answers (MCQs) focuses on “Relaxin and its Metabolic Role”.
1. Which among the following is the hormone responsible for the relaxation of pelvic tissues?
a) Relaxin
b) Progesterone
c) Estrogen
d) Oxytocin
View Answer
Explanation: Relaxin is a hormone associated with pelvic tissue and cavity relaxation that acts in combination with other conditions. Relaxin is produced in tissues of the reproductive system during pregnancy.
2. Which among the following can inactivate relaxin hormone?
a) Lyases
b) Proteolytic enzymes
c) Aromatases
d) Dehydrogenases
View Answer
Explanation: Relaxin has an average molecular weight of 9000. Proteolytic enzymes or reagents that break the S-S bond (reduction) to form SH groups inactivate it. Relaxin is a hormone released in the female reproductive system and during pregnancy by the ovary and placenta with significant effects.
3. What is the effect of relaxin in the vascularity of symphysis?
a) Constricts the bone
b) Reduces the vascularity
c) Increases the vascularity
d) Create pores
View Answer
Explanation: Relaxin’s specific influence is the increased vascularity of the symphysis connective tissue. A symphysis (fibrocartilaginous joint) is a joint in which the body (physis) of one bone meets the body of another.
4. Production of relaxin is stimulated by progesterone and other adrenocortical steroid hormones.
a) True
b) False
View Answer
Explanation: Mainly corpus luteum and placenta produces this hormone. As a result, the production is induced by progesterone and adrenocorticoid steroid hormones. Some GI troubles may be caused by progesterone, along with the hormone relaxin, such as heartburn, indigestion, constipation, and bloating.
5. Porcine relaxin is made up of four peptide chains.
a) True
b) False
View Answer
Explanation: Porcine relaxin consist of two peptide chains which contains 22 and 26 amino acids respectively. It has two S-S bonds connecting its two chains and in the A-chain it has one intra-chain S-S bond.
6. What is the role of relaxin in water balance?
a) Causes water retention
b) Causes imbibition
c) Increased water excretion
d) Increased transport of water
View Answer
Explanation: Relaxin causes imbibition of water in the body. Imbibition is a special form of diffusion that takes place as solids-colloids absorb water, triggering a volume rise. It may also affect the balance of body fluid by brain actions to induce thirst and secretion of vasopressin.
7. What effect does relaxin have in maintaining the cellular structure?
a) Splitting of collagen fibers
b) Increase collagen synthesis
c) Reduce collagen synthesis
d) Increases the synthesis of hyaluronic acid
View Answer
Explanation: Relaxin causes the dissolution and splitting of collagen fibers. This also leads to the disorganization of the fibrous structure. The absence of any improvement in the solubility of collagen following relaxin treatment of the interpubic tissue and the rapid change (16 h) in the total collagen content of the tissue indicates that the primary mechanism underlying the relaxin effect is likely to be stimulation of collagen proteolysis.
8. Which among the following activities of relaxin leads to the separation of symphysis pubis which in turn favors child birth?
a) Depolymerization of collagen fibers
b) Polymerization of collagen fibers
c) Polymerization of MPS
d) Depolymerization of MPS
View Answer
Explanation: Depolymerization of MPS of the ground material occurs as a result of relaxin activity. The above helps the symphysis pubis to be separated and the uterine cervix to be dilated and softened, enabling child birth.
Sanfoundry Global Education & Learning Series – Molecular Endocrinology.
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