Protein Engineering Internship

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Sanfoundry offers internships in "Protein Engineering". Read the complete details below regarding the internship requirements, eligibility criterior and the application process.

Pre-requisite / Skillset for Protein Engineering Internship

1. Intern should have the ability to analyze the various interactions in protein makeup.

2. Must be familiar with different levels of protein structure.

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3. Should know the role of functional proteins in various field of study.

4. Being familiar with the latest application of protein science in research.

5. Able to identify the importance of protein biomolecules.

6. Realizing the structure-function relationships in proteins.

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7. Must be familiar with the aspects of Protein Engineering in the industry.

8. Require adequate knowledge on the structure and function relationship in proteins and its application in designing proteins.

9. Must be familiar with the process of engineering proteins to increase its value by assisting folding, purification.

10. Protein engineering of therapeutic proteins, industrially important enzymes and antibodies should be known.

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11. Require knowledge about structure function relationships of proteins.

12. Must be familiar with the problem of protein folding and methods of characterization folded proteins.


Protein Engineering Internship Test

Intern has to take Protein Engineering internship test in which they will be asked 50 multiple-choice questions. They have to score grade A or A* on this test to be eligible for the internship. Here’s a sample set of questions on the Protein Engineering topic.

1. William C. Rose discovered the twentieth amino acid. Which amino acid is that?
(A) Tyrosine
(B) Tryptophan
(C) Serine
(D) Threonine
View Answer

Answer: D
Explanation: William C. Rose discovered the last and twentieth amino acid, threonine. Rose wanted to identify the nutritional content of individual amino acids. Out of the 20 amino acids, 10 are nutritionally essential. The other 10 amino acids are considered “dispensable”.
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2. Which of the following amino acid is known to form disulfide cross-links?
(A) Glutamine
(B) Valine
(C) Methionine
(D) Cysteine
View Answer

Answer: D
Explanation: Cysteine contains a sulfhydryl group in its side chain. This sulfhydryl group is reduced to form a disulfide linkage. Glutamine, valine, and methionine do not contain a sulfhydryl group; hence they cannot form disulfide linkage.

3. A polypeptide chain contains two terminals – one carboxyl-terminal (C terminal) and the other amino-terminal (N terminal). Which of the following is true?
(A) N terminal is synthesized last during translation
(B) C terminal is synthesized first during translation
(C) N terminal is represented on the right side and C terminal on the left side
(D) N terminal is represented on the left side and C terminal on the right side
View Answer

Answer: D
Explanation: During translation, the first amino acid attached has an amino free end and the last amino acid has a carboxyl free end. Hence, the N terminal is represented on the left side and C terminal on the right side.

4. Helix capping is the phenomenon in which, the side chains of which two flanking residues fold back to form hydrogen bonds with one of the four-terminal residues of the helix?
(A) Pro, Val
(B) Gly, Val
(C) Val, Ile
(D) Asn, Gln
View Answer

Answer: D
Explanation: There are some flanking residues outside the alpha-helix or beta-sheets. Helix capping is the phenomenon in which, the side chains of the flanking Asn and Gln residues fold back to form hydrogen bonds with one of the four-terminal residues of the helix.

5. Which of the following elements is not visible in the maps of X-ray crystallography?
(A) Nitrogen
(B) Carbon
(C) Oxygen
(D) Hydrogen
View Answer

Answer: D
Explanation: Hydrogen atom is not visible in the electron density maps of X-ray crystallography. The reason behind this is the low electron density of the hydrogen atom. Hydrogen contains a minimum of one electron.
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Practice the full set of Protein Engineering Multiple Choice Questions before applying for the internship.


How to apply for the Protein Engineering Internship

1. Read the Sanfoundry Internship FAQs

2. Take the Protein Engineering Internship Test

3. Submit the Internship Application Form

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Manish Bhojasia - Founder & CTO at Sanfoundry
Manish Bhojasia, a technology veteran with 20+ years @ Cisco & Wipro, is Founder and CTO at Sanfoundry. He is Linux Kernel Developer & SAN Architect and is passionate about competency developments in these areas. He lives in Bangalore and delivers focused training sessions to IT professionals in Linux Kernel, Linux Debugging, Linux Device Drivers, Linux Networking, Linux Storage, Advanced C Programming, SAN Storage Technologies, SCSI Internals & Storage Protocols such as iSCSI & Fiber Channel. Stay connected with him @ LinkedIn | Youtube | Instagram | Facebook | Twitter