Cytogenetics Internship

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Sanfoundry offers internships in "Cytogenetics". Read the complete details below regarding the internship requirements, eligibility criterior and the application process.

Pre-requisite / Skillset for Cytogenetics Internship

1. Intern must be aware of fundamental laws of genetics.

2. Types of blood groups and antigen should be known.

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3. Should be aware of concepts like sex chromosome, links, disorders and gene mapping.

4. Methods of identification of genetic material should be known.

5. Must be aware of types of genetic transfer.

6. Require adequate knowledge and understanding of methods used to identify and analyze cytogenetic aberrations.

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7. Must be familiar with the mechanism of disease expression.

8. Should have the ability to differentiate between normal and abnormal cytogenetic data.

9. Must be aware of background of human Cytogenetics.

10. Require knowledge of chromosomal abnormalities and associated disorders.

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11. Must be familiar with the comprehension of traditional and molecular techniques.


Cytogenetics Internship Test

Intern has to take Cytogenetics internship test in which they will be asked 50 multiple-choice questions. They have to score grade A or A* on this test to be eligible for the internship. Here’s a sample set of questions on the Cytogenetics topic.

1. Acyclovir is a drug used to treat viral infection by impairing its replication. Why will it not effect bacterial replication as well?
(A) Bacteria under viral attack don’t replicate
(B) Viral polymerase binds to it and thus can’t perform its function
(C) Virus uses it in a polymerization
(D) Cellular mechanism deactivates it
View Answer

Answer: C
Explanation: Acyclovir is a GMP analogue that cellular mechanism activates to GTP analogue, which the virus uses as a substrate while polymerizing. However, as it lacks 3’-OH it terminates the replication process. Thus, cellular processes activate this drug, yet its specificity to viral polymerase protects the cell.

2. What is the function of RFC in eukaryotic replication?
(A) Catalytic subunit
(B) SSB
(C) Clamp loader
(D) Primase
View Answer

Answer: C
Explanation: RFC or Replication Factor C is the eukaryotic homologue of clamp loader. It loads the PCNA clamp. Eukaryotic replication primer is formed by alpha polymerase while RPA acts as SSB.
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3. In an experiment, you are working on mitochondrial chromosomes. Which polymerase will ensure accurate replication?
(A) pol beta
(B) pol delta
(C) pol iota
(D) pol gamma
View Answer

Answer: D
Explanation: Pol gamma is the mitochondrial DNA polymerase, while pol beta is mainly necessary for repair. Pol iota associates with translesion DNA synthesis. Pol delta is the primary nuclear DNA polymerase.

4. In an experiment, you wanted to see which mutation will have worse effect on transcription. In the 1st set you deleted 94 amino acids from the C-terminus and in the 2nd set you replace the 265th C-terminal arginine to cystine. Which in your opinion will have the worst effect?
(A) 94 amino acid mutant
(B) 265th amino acid mutant
(C) Both will have similar negative effect
(D) No visible effect on rate of transcription
View Answer

Answer: C
Explanation: This is because the 265th arginine is most important for recognition of the up element. Thus, its deletion alone can have a similar negative effect on transcription to the deletion of 94 amino acids from C terminal end.

5. In a stretch of DNA being transcribed, the region forward to the Elongation is __________
(A) Positively supercoiled
(B) Negatively supercoiled
(C) Uncoiled
(D) Forms a secondary structure
View Answer

Answer: A
Explanation: The region forward to the RNA polymerase elongation machinery is positively supercoiled due to the strain. If the gyrase doesn’t release this strain the polymerizing machinery will stall. Such regions can’t be uncoiled or folded.

Practice the full set of Cytogenetics Multiple Choice Questions before applying for the internship.


How to apply for the Cytogenetics Internship

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1. Read the Sanfoundry Internship FAQs

2. Take the Cytogenetics Internship Test

3. Submit the Internship Application Form

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Manish Bhojasia - Founder & CTO at Sanfoundry
Manish Bhojasia, a technology veteran with 20+ years @ Cisco & Wipro, is Founder and CTO at Sanfoundry. He is Linux Kernel Developer & SAN Architect and is passionate about competency developments in these areas. He lives in Bangalore and delivers focused training sessions to IT professionals in Linux Kernel, Linux Debugging, Linux Device Drivers, Linux Networking, Linux Storage, Advanced C Programming, SAN Storage Technologies, SCSI Internals & Storage Protocols such as iSCSI & Fiber Channel. Stay connected with him @ LinkedIn | Youtube | Instagram | Facebook | Twitter