This set of Virology Multiple Choice Questions & Answers (MCQs) focuses on “Mumps Viruses”.
1. Which of the following is the local symptom of mumps?
a) Swelling of pancreatic glands
b) Swelling of salivary glands
c) Swelling of testes
d) Swelling of adrenal glands
Explanation: The mumps virus is a virus that causes the swelling of salivary glands and this results in the enlargement of glands due to parotitis. It also gives rise to the rashes on the skin.
2. Who observed the infection of the CNS due to mumps virus?
Explanation: Hamilton in the year 1790, first noted some cases of infection of the central nervous system (CNS) and meninges due to mumps virus. Hippocrates noted the swelling of testes or orchitis as a common complication of mumps.
3. The mumps virus belongs to the genus ______________
Explanation: The mumps virus belongs to the genera Rubulavirus and is classified under the Paramxyoviridae family. It contains a non-segmented negative-stranded RNA genome and has hemagglutinin and neuraminidase activity.
4. Which of the following is a canine parainfluenza virus?
Explanation: Simian virus 5 (SV5) is also referred to as canine parainfluenza virus and it was first isolated from rhesus and cynomolgus monkey kidney-cell cultures. Thus, it is designated as a primate virus.
5. Which of the following does not inactivates or harms mumps virus?
c) UV radiation
Explanation: The mumps virus virion is susceptible to heat and treatment with ultraviolet light. The virus gets inactivated by 0.2% formalin and the presence of the lipid bilayer confers sensitivity to both ether and chloroform.
6. Which of the following protein has RdRp polymerase activity?
Explanation: The Large protein (L) has got RdRp polymerase activity that is associated with ribonucleoprotein (RNP). It has many roles in capping, methylation, and polyadenylation. The size of protein on the SDS page is more than 200.
7. Which of the following protein contains the cysteine-rich domain?
Explanation: NS1 protein contains a cysteine-rich domain. It is a non-structural phosphorylated protein involved in metal binding. It leads to proteasomal degradation of STAT1 and targets STAT3 for ubiquitination. It is also known as non-structural V protein.
8. Which of the following is a very rare medical condition of mumps virus infection?
a) Swelling of salivary glands
b) Permanent deafness
c) Depression of sperm production
d) CMI response in the absence of humoral response
Explanation: Permanent deafness is a very rare medical condition of mumps virus infection and the frequency of deafness is less than 3%. The swelling of salivary glands, depression of sperm production, CMI response in absence of humoral response are common or frequently occurring conditions due to mumps virus infection.
9. Which of the following is a hydrophobic protein?
c) Non-structural W
Explanation: The matrix protein (M) is a hydrophobic protein that is associated with the inner side of the membrane. It plays a role in budding by interactions with N, HN, and F proteins. Non-structural W, large and nucleocapsid are phosphorylated proteins.
10. The mumps virus a monotypic virus.
Explanation: The mumps virus (MuV) is a monotypic virus and the tests with human sera indicate the existence of only a single serotype. This means that they have only one species.
11. The mumps virus is transmitted by saliva.
Explanation: The mumps virus replicates in the upper respiratory tract and the salivary glands and is transmitted by saliva. It spreads from person to person through salivary droplets. It is highly contagious.
Sanfoundry Global Education & Learning Series – Virology.
To practice all areas of Virology, here is complete set of 1000+ Multiple Choice Questions and Answers.