This set of Virology online test focuses on “Humans Viruses – Flaviviridae and Filoviridae”.
1. The hepatitis C virus was discovered in __________
a) 1999
b) 1989
c) 1985
d) 1979
View Answer
Explanation: The hepatitis C virus was discovered in the year 1989 by a tour de force of molecular biology. Its virion has neither been visualized nor cultivated and it is the most common cause of posttransfusion hepatitis.
2. The Flavivirus consists of ____________ as its genome.
a) ssDNA
b) dsDNA
c) dsRNA
d) ssRNA
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Explanation: The Flavivirus consists of single-stranded RNA as its genome. It is a single linear 11kb molecule of positive polarity. It is capped at 5’ end but not polyadenylated at 3’ end and hence, it is infectious.
3. The proliferation of flavivirus is accompanied by the _____________
a) mitochondria
b) nucleus
c) endoplasmic reticulum
d) golgi body
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Explanation: The proliferation of flavivirus is accompanied by both smooth endoplasmic reticulum (SER) and rough endoplasmic reticulum (RER). The replication occurs in the cytoplasm and the incoming RNA directly serves as a messenger.
4. In which of the following case the virus replicates in Kupffer cells?
a) Yellow fever
b) Dengue fever
c) Malaria fever
d) Sandfly fever
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Explanation: Yellow fever is a hemorrhagic fever in which the liver is the major target and the virus replicates in the Kupffer cells. This results in a decrease in the rate of formation of prothrombin and leads to jaundice.
5. Which of the following virus is maintained in a Culex – bird cycle?
a) West Nile virus
b) Kunjin virus
c) Tick-borne virus
d) Dengue virus
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Explanation: The West Nile virus is maintained in a Culex – bird cycle. It is an endemic disease and causes illness like dengue and sometimes also causes encephalitis. It also infects ticks.
6. The size of HCV genome is _____________
a) 10 kb
b) 10.5 kb
c) 9.5 kb
d) 9 kb
View Answer
Explanation: The size of the hepatitis C virus genome is 9.5 kilobases. It consists of single-stranded RNA of positive polarity. It encodes a polyprotein of about 3000 amino acids flanked by untranslated sequences.
7. The filoviruses are classified as __________________ pathogens.
a) Biosafety level 4
b) Biosafety level 1
c) Biosafety level 3
d) Biosafety level 2
View Answer
Explanation: The filoviruses are classified as Biosafety level 4 pathogens. It must be handled only in maximum security laboratories. It can be isolated from blood and can also be grown well in Vero cells.
8. The filovirus replication is marked by the formation of inclusion bodies.
a) True
b) False
View Answer
Explanation: The filovirus replication is marked by the formation of inclusion bodies and the replication occurs exclusively in the cytoplasm of the cell. It replicates well in Vero cells, monkeys, etc. and the maturation occurs via budding from the plasma membrane.
9. The virions of the Filoviridae members are composed of lipid bilayers.
a) True
b) False
View Answer
Explanation: The virions of the Filoviridae members are composed of lipid bilayers. They are very long filamentous rods or more compact convoluted forms, each composed of lipid bilayers covered with peplomers.
Sanfoundry Global Education & Learning Series – Virology.
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