Virology Questions and Answers – Chemotherapy of Viral Diseases

«
»

This set of Virology Multiple Choice Questions & Answers (MCQs) focuses on “Chemotherapy of Viral Diseases”.

1. Which of the following agent targets ligand on virion?
a) Protease inhibitor
b) Disoxaril
c) Tat inhibitor
d) Zidovudine
View Answer

Answer: b
Explanation: Disoxaril is an antiviral agent that targets the ligand on virion. It prevents the structural transition required for viral uncoating which results in inhibition of the reproduction of the virus.
advertisement

2. Who developed a prodrug that depends on a viral enzyme to convert into its active form?
a) Elion
b) Watson
c) Crick
d) Pasteur
View Answer

Answer: a
Explanation: Elion and his colleagues in the year 1977 developed a prodrug that depends on a viral enzyme to convert into its active form. It was a breakthrough in antiviral chemotherapy in 1977.

3. The chemical name of acycloguanosine is ____________
a) 9-(2-hydroxyethoxymethyl) guanine
b) 9-(3-hydroxymethoxyethyl) guanine
c) 7-(2-hydroxymethoxymethyl) guanine
d) 7-(1-hydroxyethoxyethyl) guanine
View Answer

Answer: a
Explanation: The chemical name of acycloguanosine is 9-(2-hydroxyethoxymethyl) guanine and is commonly known as acyclovir. It is a guanine derivative with an acyclic side chain.
advertisement
advertisement

4. Ribavirin was first synthesized in __________
a) 1988
b) 1970
c) 1978
d) 1972
View Answer

Answer: d
Explanation: Ribavirin was first synthesized in the year 1972 however, it has still not been licensed for general use in many countries. It is a nucleoside analog, 1-β-D-ribofuranosyl-1, 2, 3, 4-triazole-3-carboxamide that inhibits the growth of a wide spectrum of RNA and DNA viruses.

5. Which of the following blocks the DNA polymerase of the herpes virus?
a) Trisodium phosphonoformate
b) Ganciclovir
c) Ribavirin
d) Acycloguanosine
View Answer

Answer: a
Explanation: Trisodium phosphonoformate blocks the DNA polymerase of the herpes virus as well as the hepatitis B virus. It also blocks the reverse transcriptase enzyme of HIV viruses by blocking the pyrophosphate binding site on the enzyme.
advertisement

6. Endosomes are involved in uncoating of the incoming virion.
a) True
b) False
View Answer

Answer: a
Explanation: Endosomes are involved in the uncoating of incoming virions. These are called acidic endosomes and M2 protein forms the tetrameric transmembrane ion channel which reduces pH gradient in acidic endosomes. These endosomes also help in the transport of newly synthesized hemagglutinin from the trans-Golgi cisternae to the plasma membrane.

7. Interferons are more effective orally.
a) True
b) False
View Answer

Answer: b
Explanation: Interferons are not effective orally or by mouth. Therefore, they are injected using injections. They display a broad sense of activity against all essential viruses.
advertisement

Sanfoundry Global Education & Learning Series – Virology.

To practice all areas of Virology, here is complete set of 1000+ Multiple Choice Questions and Answers.

advertisement

Participate in the Sanfoundry Certification contest to get free Certificate of Merit. Join our social networks below and stay updated with latest contests, videos, internships and jobs!

advertisement
advertisement
Manish Bhojasia - Founder & CTO at Sanfoundry
Manish Bhojasia, a technology veteran with 20+ years @ Cisco & Wipro, is Founder and CTO at Sanfoundry. He is Linux Kernel Developer & SAN Architect and is passionate about competency developments in these areas. He lives in Bangalore and delivers focused training sessions to IT professionals in Linux Kernel, Linux Debugging, Linux Device Drivers, Linux Networking, Linux Storage, Advanced C Programming, SAN Storage Technologies, SCSI Internals & Storage Protocols such as iSCSI & Fiber Channel. Stay connected with him @ LinkedIn | Youtube | Instagram | Facebook | Twitter