This set of Virology Questions and Answers for Entrance exams focuses on “Coxsackieviruses, Echoviruses, and Enteroviruses”.
1. The Coxsackie viruses were discovered in the late _____________
Explanation: The Coxsackie viruses were discovered in the late 1940s as a result of intense efforts to develop a better system to propagate and study poliovirus. The non-human primates were the model system for poliovirus and poliomyelitis at this time.
2. Which of the following induce polio-like paralysis in the monkey?
Explanation: CVA7 can induce polio-like paralysis in monkeys. However, swine vesicular disease virus is closely related genetically and antigenically to CVB5. The infection of non-human primates often fails to induce clinical disease, but CVA7 can induce it in the monkeys.
3. CVA9 uses ____________ as a host cell receptor.
Explanation: CVA9 uses integrin αvβ3 as a host cell receptor. Coxsackievirus-adenovirus receptor (CAR) and decay-accelerating factor (DAF) is used by CVB1-6 and intracellular adhesion molecule 1 (ICAM-1) is used by HEV-C coxsackie viruses.
4. Which of the following is associated with acute hemorrhagic conjunctivitis?
Explanation: CVA24 is mainly associated with acute hemorrhagic conjunctivitis. This disease is different from other enteroviral illness, having occurred in global pandemics since 1969. Enterovirus 70 is also associated with this disease.
5. Which of the following is higher in patients than in controls in case of acute myocarditis?
Explanation: It has been shown that CVB IgM in a group of patients is significantly higher than in controls. The RNA of enterovirus has also been detected in myocardial biopsy specimens from patients with myocarditis.
6. Which of the following is called Bornholm disease?
Explanation: Pleurodynia is also known as Bornholm disease in which a painful inflammation of the muscles mainly intercoastal or abdominal muscles, occur. The pain may be severe and resemble ischemic heart disease or acute abdomen.
7. Which of these is mainly seen in children?
a) Mouth disease
d) Hand disease
Explanation: Herpangina is the illness that is seen mainly in children. There is a pain in swallowing and usually a slight fever of a few day duration. Differential diagnosis is herpes simplex, varicella, aphthous stomatitis.
8. Which of the following is a disease caused by echovirus infection?
a) Neonatal meningitis
c) Foot disease
Explanation: Rashes are seen frequently in echovirus infections and they are non-specific and rubelliform. It is accompanied by fever and pharyngitis and a rash is seen sometimes in the course of meningitis. The Coxsackie A virus infections also cause rashes.
9. The echovirus possesses _____________ as their genome.
Explanation: The echovirus possesses single-stranded RNA as their genome of positive polarity which functions as mRNA. The RNA is surrounded by a protein shell (capsid) with icosahedral symmetry.
10. Echovirus is resistant to lipid solvents.
Explanation: Echovirus is resistant to lipid solvents and they retain their infectivity at pH 3 to 9. They are stable at room temperature for several days. They are small and roughly spherical with the ssRNA genome.
11. Inoculation of coxsackievirus in mice will lead to death.
Explanation: The inoculation of coxsackievirus in the newborn mice will lead to disease and death. The cytopathic effect (CPE) is observed after a few days and neutralization tests are used for virus identification.
Sanfoundry Global Education & Learning Series – Virology.
To practice all areas of Virology for Entrance exams, here is complete set of 1000+ Multiple Choice Questions and Answers.
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