This set of Bioinformatics Multiple Choice Questions & Answers (MCQs) focuses on “Needleman – Wunsch Algorithm”. 1. Which of the following is not the objective to perform sequence comparison? a) To observe patterns of conservation b) To find the common motifs present in both sequences c) To study the physical properties of molecules d) To … Read more
This set of Bioinformatics Multiple Choice Questions & Answers (MCQs) focuses on “Heuristic Algorithms”. 1. Which of the following is untrue regarding the Progressive Alignment Method? a) Progressive alignment depends on the stepwise assembly of multiple alignments and is heuristic in nature b) It speeds up the alignment of multiple sequences through a multistep process … Read more
This set of Bioinformatics Multiple Choice Questions & Answers (MCQs) focuses on “Exhaustive Algorithms”. 1. Related sequences are identified through the database similarity searching and as the process generates multiple matching sequence pairs, it is often necessary to convert the numerous pair wise alignments into a single alignment. a) True b) False 2. There is … Read more
This set of Bioinformatics Multiple Choice Questions & Answers (MCQs) focuses on “Statistical Significance of Sequence Alignment”. 1. The truly statistically significant sequence alignment will be able to provide evidence of homology between the sequences involved. a) True b) False 2. By calculating alignment scores of a large number of ______ sequence pairs, a distribution … Read more
This set of Bioinformatics Multiple Choice Questions & Answers (MCQs) focuses on “Methods”. 1. The overall goal of pair wise sequence alignment is to find the best pairing of two sequences, such that there is maximum correspondence among residues. a) True b) False 2. In local alignment, the two sequences to be aligned cannot be … Read more
This set of Bioinformatics test focuses on “Sequence Homology Versus Sequence Similarity and Identity”. 1. Which of the following is incorrect regarding pair wise sequence alignment? a) The most fundamental process in this type of comparison is sequence alignment b) It is an important first step toward structural and functional analysis of newly determined sequences … Read more
This set of Bioinformatics Multiple Choice Questions & Answers (MCQs) focuses on “Bayesian Statistics”. 1. By whom and when were the Bayesian methods applied first? a) Smith-Waterman, 1981 b) Agarwal and States, 1996 c) Smith-Waterman, 1996 d) Agarwal and States, 1981 2. With the application of Bayesian methods, the most probable repeat length and evolutionary … Read more
This set of Bioinformatics Interview Questions and Answers for Experienced people focuses on “Assessing the Significance of Sequence Alignments”. 1. On analysis of the alignment scores of random sequences will reveal that the scores follow a different distribution than the normal distribution called the _________ a) Gumbel equal value distribution b) Gumbel extreme value distribution … Read more
This set of Bioinformatics Questions and Answers for Experienced people focuses on “Use of Scoring Matrices and Gap Penalties in Sequence Alignments”. 1. In scoring matrices, for convenience, odds scores are converted to log odds scores. a) True b) False 2. Which of the following doesn’t describe PAM matrices? a) This family of matrices lists … Read more
This set of Bioinformatics Multiple Choice Questions & Answers (MCQs) focuses on “Dynamic Programming Algorithm for Sequence Alignment”. 1. Use of the dynamic programming method requires a scoring system for the comparison of symbol pairs, and a scheme for GAP penalties. a) True b) False 2. After the derivation, the outputs of the dynamic programming … Read more
