Pre-requisite / Skillset for Molecular Endocrinology Internship
1. Intern should be familiar with the basic terminologies of hormones, classification of hormones based on its chemistry.
2. Ability to deduce the structure of amino acid derived, protein and steroid hormones.
3. Ability to understand the synthesis of various hormones by respective gland.
4. Understanding the regulation of hormones action by feedback mechanism.
5. Able to understand the mechanism of action of steroid hormones.
6. Must be familiar the mechanism of action of pancreatic hormones.
7. Require knowledge on the mechanism of action of thyroid hormones.
8. Must be aware of the mechanism of action of sex hormones.
9. Ability to demonstrate various types of second messengers and their action.
10. Should be familiar with the various functions of thyroid, pancreatic and sex hormones.
11. Ability to demonstrate the dysfunction of various endocrine glands.
Molecular Endocrinology Internship Test
Intern has to take Molecular Endocrinology internship test in which they will be asked 50 multiple-choice questions. They have to score grade A or A* on this test to be eligible for the internship. Here’s a sample set of questions on the Molecular Endocrinology topic.
1. How are enzymes purified and detected?
(A) Quantitative Bioassays
(B) Enzyme assays
Explanation: The scientists carry out the fractionation of extracts containing the putative hormone to extract a pure hormone. They use the same methods used to purify other biomolecules (solvent fractionation, chromatography, and electrophoresis), and then assays each fraction for testing the activity of hormones. It is possible to determine its composition and structure after the chemical has been purified.
2. What is the name of the hormone injected by millions of people with diabetes mellitus?
Explanation: Insulin is the hormone used by diabetes patients. To compensate for the lack of development of this essential hormone from their own pancreatic cells, millions of people with type 1 diabetes mellitus inject themselves with pure insulin daily. Insulin injection is not a solution for diabetes, but it facilitates healthy and prosperous lives for persons who may otherwise have died early.
3. Where do hormones bind to activate the target cells in specific tissues?
Explanation: In hormone-sensitive target cells, all hormones function through highly specialized receptors, to which they bind with high affinity. Each type of cell has its own hormone receptor combination, determining the range of its hormone responsiveness.
4. What are the three classifications of hormones based on their mode of release into the target tissue?
(A) Peptide, Catecholamines and eicosanoids
(B) Endocrine, Paracrine and Autocrine
(C) Steroids, Vitamins and Retinoids
(D) Exocrine, Autocrine and Paracrine
Explanation: Endocrine hormones are directly released into the blood stream and are carried to the target tissues in the body. Paracrine hormones are released and diffused into the target tissue through the extracellular space. Autocrine hormones are the ones that bind to the receptors in the same cell/tissue that release them.
5. Name a hormone which is produced from vitamin D?
Explanation: Hydroxylation reactions in the liver and kidneys produces calcitriol (1,25-dihydroxycholecalciferol) from vitamin D. Vitamin D can be obtained in two ways; either from the diet or by the photolysis of 7-dehydrocholesterol in the skin which is exposed to sunlight.
Practice the full set of Molecular Endocrinology Multiple Choice Questions before applying for the internship.
How to apply for the Molecular Endocrinology Internship
1. Read the Sanfoundry Internship FAQs
2. Take the Molecular Endocrinology Internship Test
3. Submit the Internship Application Form
Participate in the Sanfoundry Certification contest to get free Certificate of Merit. Join our social networks below and stay updated with latest contests, videos, internships and jobs!