Pre-requisite / Skillset for Bioinformatics Internship
1. Intern must have the ability to develop bioinformatics tools with programming skills.
2. Must apply computational based solutions for biological perspectives.
3. Intern must be familiar with the concepts of Bioinformatics.
4. Intern should know the recent evolution in biological science.
5. Intern must be familiar with the relevant online resources, databases and software tools.
6. Should be capable of applying alignment and modelling tools.
7. Intern must be able to analyse the biological data using phylogenetic, predictive and comparative methods.
8. Should have knowledge on various tools in bioinformatics to manipulate and analyse biological data.
9. Should be aware of various tools used in bioinformatics to manipulate and analyse biological data.
10. Should know how to design in silico various biomolecules.
Bioinformatics Internship Test
Intern has to take Bioinformatics internship test in which they will be asked 50 multiple-choice questions. They have to score grade A or A* on this test to be eligible for the internship. Here’s a sample set of questions on the Bioinformatics topic.
1. In the zinc finger, which residues in this sequence motif form ligands to a zinc ion?
(A) Cysteine and histidine
(B) Cysteine and arginine
(C) Histidine and proline
(D) Histidine and arginine
Explanation: In the zinc finger, which is found in a widely varying family of DNA-binding proteins, cysteine and histidine residues in this sequence motif form ligands to a zinc ion whose coordination is essential to stabilize the tertiary structure.
2. While analysing motif sequences, what is the major disadvantageous feature of PROSITE?
(A) The database constructs profiles to complement some of the sequence patterns
(B) The functional information of these patterns is primarily based on published literature
(C) Some of the sequence patterns are too short to be specific
(D) Lack of specificity about probability and variation and relation between them
Explanation: The major pitfall with the PROSITE patterns is that some of the sequence patterns are too short to be specific. Rest of the options are advantages. The problem with these short sequence patterns is that the resulting match is very likely to be a result of random events. Overall, PROSITE has a greater than 20% error rate. Thus, either a match or non-match in PROSITE should be treated with caution.
3. Sequence similarity and sequence identity are synonymous for nucleotide sequences and protein sequences as well.
Explanation: Sequence similarity and sequence identity are synonymous for nucleotide sequences. For protein sequences, however, the two concepts are very different. In a protein sequence alignment, sequence identity refers to the percentage of matches of the same amino acid residues between two aligned sequences. Similarity refers to the percentage of aligned residues that have similar physicochemical characteristics and can be more readily substituted for each other.
4. Which of the following is untrue about dot plot method and its applications?
(A) This method gives a direct visual statement of the relationship between two sequences
(B) One of its advantages is the identification of sequence repeat regions based on the presence of parallel diagonals of the same size vertically or horizontally in the matrix
(C) It is not useful in identifying chromosomal repeats
(D) The method can be used in identifying nucleic acid secondary structures through detecting self-complementarity of a sequence
Explanation: It is useful in identifying chromosomal repeats and in comparing gene order conservation between two closely related genomes. The dot matrix method gives a direct visual statement of the relationship between two sequences and helps easy identification of the regions of greatest similarities. The method thus has some applications in genomics.
5. The major disadvantage of the PRSS program is that it doesn’t allow partial shuffling.
Explanation: The major feature of the program is that it allows partial shuffling. For example, shuffling can be restricted to residues within a local window of 25–40, whereas the residues outside the window remain unchanged.
Practice the full set of Bioinformatics Multiple Choice Questions before applying for the internship.
How to apply for the Bioinformatics Internship
1. Read the Sanfoundry Internship FAQs
2. Take the Bioinformatics Internship Test
3. Submit the Internship Application Form
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