14 Best Books on Structural Biology

“Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology” Book Review: This book describes the fundamentals, practices, and applications of protein crystallography. This book has been illustrated in full-color. The book describes mathematical and physical concepts in accessible and accurate language. It highlights key concepts for understanding the practice and analysis of protein crystal structures. The book contains examples of biologically-relevant molecules, complexes, and drug target structures. This book will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.

“Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell: 6 (Series in Structural Biology)” Book Review: This book reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones. It provides essential kinetic assistance to processes of protein folding and unfolding in the cell. The book illustrates each type of chaperone by X-ray and EM structure determinations at near- atomic level resolution. It is described by a leader in the study of the respective family. This book can be used by students and researchers of structural biology.

“Introduction to Protein Architecture: The Structural Biology of Proteins” Book Review: This book is written in a clear and engaging style and has several illustrations with computer graphics. The emphasis of this book is on protein architecture, on proteins as three-dimensional patterns. This book introduces the use of the World Wide Web in bioinformatics. This book explains the general characteristics of proteins that underlie the great variety of folding patterns observed in nature. This book is for second and third year undergraduate students and beginning postgraduate students. It will be of interest to all biological and medical scientists whose work touches on proteins.

Fundamentals of Protein NMR Spectroscopy (Focus on Structural Biology)” Book Review: This book helps study the structure and dynamics of biological macromolecules. This book gives a basic understanding of the phenomenological properties of magnetic resonance. The book also explains the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. The book begins with elementary quantum mechanics where a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multinuclear NMR pulse sequences. The book gives a modular analysis of NMR pulse sequence building blocks which provides a basis for understanding and developing novel pulse programs. It covers topics from chemical shift assignment to protein structure refinement to the analysis of protein dynamics and chemical kinetics. The book also provides a practical guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing. There are end of chapter exercises that are included to emphasize important concepts. This book offers students a systematic, in-depth, understanding of modern NMR spectroscopy. The application of this book to biomolecular systems will also be useful for the experienced investigator.

“Structural Aspects of Protein Synthesis: (Series in Structural Biology)” Book Review: This book provides a description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a detailed overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation.

“Molecular Structures and Structural Dynamics of Prion Proteins and Prions (Focus on Structural Biology)” Book Review: This book is designed for practitioners in computing of biophysics, biochemistry, etc. This is an easy-to-read-and-understand book on prion proteins’ molecular dynamics (MD) simulations and on prions’ molecular modelling (MM) constructions. This book enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. This book’s MD studies on species are helpful to understand the mechanism underlying the resistance to prion diseases. This book also studies the unstructured region through MD and especially MM techniques from the global optimization point of view. This book is ideal for practitioners in computing of biophysics, biochemistry, biomedicine, bioinformatics and cheminformatics. It is also useful for practitioners and students in materials science and engineering, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc.

“Data Mining in Structural Biology: Signal Transduction and Beyond (Ernst Schering Foundation Symposium Proceedings)” Book Review: This book talks about structural biology becoming a routine technique for structure determination in pharmaceutical industries. This book talks about the numerous initiatives in the field of “structural genomics” that are distributed all over the world. These have led to the development of techniques for high-throughput structure determina­tion. This structural information is being explored in various ways in the drug discovery process. This book also discusses the technique of structure-sequence compatibility (threading) that is increasingly used to assign a function to a given protein fold. This book will be useful for students and researchers in the field of structural biology.

“Computational Structural Biology: Methods and Applications” Book Review: This book can be used as a guide for both students and practitioners. It provides a comprehensive overview of the major changes in the field of computational methods in structural biology. The book discusses the effect of computational methods with respect to protein structure and design. The book at the end of each chapter, other than the summary, the future of the field has been discussed, along with its challenges.

“Computational and Structural Approaches to Drug Discovery: Ligand-Protein Interactions (RSC Biomolecular Sciences, Volume 8) 1st Edition” Book Review: This book is designed for all graduate level courses covering molecular interactions and drug discovery. It also provides references for the professionals in the pharmaceutical industry. The book highlights and explores both structural and chemical design of drug design. All factors necessary to encode, such as absorption, toxicology etc have been discussed. The book provides a detailed understanding of docking along with comparison and analysis of the methods and an insight into scoring algorithms.

“Lecture Notes on Computational Structural Biology” Book Review: This book aims to reduce the gap between the rapid developments in the field of structural bioinformatics. It is a collection of lecture notes, extensive research and the authors own knowledge about the subject field. It also provides content from the viewpoint of a computer scientist or applied mathematician. The book will help understand the importance of mathematics in this field.

“Bayesian Methods in Structural Bioinformatics (Statistics for Biology and Health) 2012th Edition” Book Review: the book provides an overview of the current statistical methods used to solve problems in structural bioinformatics. It talks about statistical methods within the framework of statistical physics. The book deals with biomolecular structure in atomic details. The book begins with basic introduction and assumes minimum knowledge of proteins and mathematics.

“Structural Genomics and Drug Discovery: Methods and Protocols (Methods in Molecular Biology (1140)” Book Review: This book provides the methods and protocols for the discovery of structure of drugs. It provides all steps and tools required to canary out the procedures in a laboratory. The book also provides tips to avoid potential drawbacks.

“Advance in Structural Bioinformatics (Advances in Experimental Medicine and Biology (827)) 2015th Edition” Book Review: This book is designed for researchers and students in the fields of bioinformatics, computational biology and chemistry. The book details mathematical and physical modelling with the help of case studies and researches. The book provides information on structure bioinformatics at different levels. The chapters move from basics to the advanced. It also provides guidelines on acquiring and analyzing genomics and proteomics sequences, protein structures etc.

“Structural Bioinformatics 2nd Edition” Book Review: This book is designed for graduate and undergraduate university courses. The book provides the applications and the basic principles in the field of structural bioinformatics. The book is updated with newer developments in the field. The book includes topics such as sampling and search techniques; use of mass spectrometry etc.