28 Best Books on Systems Biology

We have compiled a list of the Best Reference Books on Systems Biology, which are used by students of top universities, and colleges. This will help you choose the right book depending on if you are a beginner or an expert. Here is the complete list of Systems Biology Books with their authors, publishers, and an unbiased review of them as well as links to the Amazon website to directly purchase them. If permissible, you can also download the free PDF books on Systems Biology below.

1. Introduction to Systems Biology

 
1."An Introduction to Systems Biology: Design Principles of Biological Circuits" by Alon U
Book Review: This book provides an overview of the design principles of biological systems, and highlights the recurring circuit elements that are used to build up biological networks. It also presents a simple mathematical framework that can be used for design and understanding of biological circuits. The book focuses on biological systems that illustrate key principles and concepts, and sets up a strong foundation for the better understanding of general principles. The book also helps the readers to question the design of a system and go ahead to answer it with simplified models.

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2."Mathematical Biology: An Introduction" by Murray J
Book Review: This comprehensive textbook covers the latest advancements in the field of mathematical biology, providing practical applications of mathematical modeling through numerous exercises from various bioscience disciplines, including population biology, developmental biology, physiology, epidemiology, and evolution. It is an ideal resource for graduate students seeking to enhance their knowledge and skills in this field.

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3."An Introduction to Mathematical Biology" by Linda J S Allen
Book Review: This book introduces various mathematical models for different biological systems, along with the mathematical theory and techniques used to analyze them. It also contains mathematical theory applications and many biological examples. The book concentrates on deterministic mathematical models, thus stressing on qualitative behavior prediction. It also discusses Leslie matrix model, Nicholson Bailey model, Lotka Volterra prey model and many more. The book also exposes many mathematical models in biology.

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4."Introduction to Systems Biology" by Sangdun Choi
“Introduction to Systems Biology” Book Review: The book introduces the subject of computational methods for research and concepts of systems biology to undergraduate and graduate students alike, with an overview of the subject using examples and methods of experimental design. The book contains a total of 25 chapters with numerous illustrations, which aid readers in a better understanding of the subject. The book begins with an introduction to systems biology and then discusses experimental omics tools. Few of the other sections target various computational methods approaches to understanding of the biological dynamic systems. Gradually, the book proceeds towards theoretical and modeling optimization in systemic biological research. The book provides vital information on bioinformatic programs and available successful applications. This book acts as an introduction to computational methods for research and concepts of systems biology.

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5."Introduction to Biology" by National Agricultural Institute
“Introduction to Biology” Book Review: This book is part of the Just The Facts (JTF) series, which aims to provide basic introductions to various topics in agriculture, food, and natural resources for secondary and postsecondary students. The book provides a basic introduction to biology, broadly covering topics such as cells, tissues, organs, and systems. The content of the book is aided by learning objectives, key terms at the beginning of every section, references and short assessments at the end of every section. The novel approach of the book enables it to interact with the students even in the form of complementary PowerPoint presentations. A number of QR scan codes are provided in the book, which can be scanned by the readers’ mobile phone/tablet for further reading on various websites. The book is available in both print and digital formats for efficient availability.

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6."Life: An Introduction to Complex Systems Biology" by Kaneko Kunihiko
“Life: An Introduction to Complex Systems Biology” Book Review: This book provides a novel, non-reductionist perspective on our perception of molecular biology. It emphasizes universal properties of living systems and the construction of a phenomenological theory of life. The book discusses in detail complex processes such as reproductive cellular systems, evolution, and differentiation. Starting with an approach to the study of living systems, the book proceeds to key topics such as constructive biology and the origin of bioinformation. A few other concepts described are cell differentiation and development, pattern formation and the origin of positional information, genetic evolution with phenotypic fluctuations, and speciation as a fixation of phenotypic differentiation. The book concludes with a detailed summary of all the aforementioned topics. The terminology is simple for easier understanding by students.

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7."Mathematical Modeling in Systems Biology: An Introduction" by Ingalls Brian P
“Mathematical modeling in systems biology: An introduction” Book Review: The focus of this book is on using mathematical approaches to comprehend and interpret models in molecular systems biology. It is suitable for undergraduate or graduate students in life science or engineering who have a background in calculus. The first half of the book introduces the basics of mathematical modeling in molecular systems biology. The second half of the book, comprising the last four sections, delves into specific biological domains, including metabolic networks, signal transduction pathways, gene regulatory networks, and electrophysiology and neuronal action potentials. Optional sections with more specialized modeling topics are provided in chapters 3-8. The book includes exercises throughout, and the end-of-chapter exercises may require computational software. The appendices provide a review of molecular biology and concepts, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB).

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8."Introduction to Modeling Biological Cellular Control Systems" by Liu
“Introduction to modelling biological cellular control systems” Book Review: The discussed book provides insights into modeling, simulation, analysis, and applications of biological cellular control systems. The book explains the use of laws of mass balance and mass action to derive enzyme kinetic models, such as the Michaelis-Menten function and the Hill function. The book also demonstrates how to use current-voltage relations and the Nernst potential equilibrium equation in modeling. The book emphasizes approaches for estimating model parameters and numerical solving of models using MATLAB for computer simulations. Additionally, the book includes methods for conducting model analyses. The content is presented in a clear and easily understandable language.

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9."Introduction to Biosemiotics : The New Biological Synthesis" by Barbieri
“Introduction to Biosemiotics: The New Biological Synthesis” Book Review: This book is a valuable resource for graduate students and beyond, as it delves into the fascinating field of biosemiotics. The concept of biosemiotics is explored as the process of cellular organisms converting objective signals into conventional signs. Starting with a comprehensive history of biosemiotics, the book offers an overview of the latest research in the field. The chapters are self-contained, making it easy for readers to navigate specific topics of interest. Additionally, the book includes numerous references for further reading and a detailed index for quick and easy referencing.

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2. Computational Systems Biology

 
1."Systematic: How Systems Biology Is Transforming Modern Medicine" by James R Valcourt
“Systematic: How Systems Biology Is Transforming Modern Medicine” Book Review: This book is an accessible introduction to systems biology, which studies how networks of proteins work together in the body. It provides insights into maintaining and promoting health when these systems malfunction. The book covers topics such as gene regulation, inheritance, cancer drugs, and personalized treatments based on an individual’s unique genetic makeup. It also explores the role of gut microbes in nutrition and obesity, as well as new remedies that harness the body’s natural defenses. This book is recommended for anyone interested in systems biology or related fields.

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2."Morphogenesis and Pattern Formation in Biological Systems: Experiments and Models" by Toshio Sekimura and N Ueno
“Morphogenesis and Pattern Formation in Biological Systems: Experiments and Models” Book Review: This book covers a wide range of research fields, such as developmental biology, molecular biology, plant morphogenesis, ecology, epidemiology, medicine, palaeontology, evolutionary biology, mathematical biology, and computational biology. It provides a comprehensive overview of the field of morphogenesis and pattern formation, and integrates experimental and theoretical aspects of biology to construct and investigate models of complex processes. The book is a valuable resource for anyone interested in learning more about this fascinating field.

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3."Transactions on Computational Systems Biology I (Lecture Notes in Computer Science)" by Corrado Priami
“Transactions on Computational Systems Biology I (Lecture Notes in Computer Science)” Book Review: This book is a comprehensive collection of research papers edited by Corrado Priami. The book covers various topics related to computational systems biology, including network models, gene expression, metabolic pathways, and signal transduction. The research papers provide new insights into the computational analysis of biological systems, and the book also features discussion on the application of various computational tools, such as Petri nets, process calculi, and rule-based systems. This book is a valuable resource for researchers and students interested in the interdisciplinary field of computational systems biology.

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4."An Introduction to Systems Biology: Design Principles of Biological Circuits (Chapman & Hall/CRC Mathematical and Computational Biology)" by Uri Alon
“An Introduction to Systems Biology: Design Principles of Biological Circuits (Chapman & Hall/CRC Mathematical and Computational Biology)” Book Review: This book presents the design principles that are common in biological systems. It highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework that can be used to understand and even design biological circuits. This book avoids specialist terms, focusing instead on a few well-studied biological systems that demonstrate key principles in a concise way. It builds a solid foundation for the intuitive understanding of general principles.

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5."Computational Systems Biology: From Molecular Mechanisms to Disease" by Andres Kriete and Roland Eils
“Computational Systems Biology: From Molecular Mechanisms to Disease” Book Review: This book explores the experimental and theoretical foundations of the function of biological systems at the molecular, cellular, and organismal levels. It covers the work that focuses on the engineering of biological systems and network modeling. It covers logical information flow and helps understanding basic building blocks of life through disease phenotypes. Its evolved principles give insight into underlying organizational principles of biological organizations and systems processes, governing functions such as adaptation or response patterns. The book also covers various technical tools and systems which help researchers to understand and resolve specific systems biology problems using advanced computation. This book covers multi-scale modeling on disparate scales, aiding researchers in the understanding of dependencies and constraints of Spatio-temporal relationships fundamental to biological organization and function.

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6."Modeling in Systems Biology: The Petri Net Approach (Computational Biology)" by imusti
“Modeling in Systems Biology: The Petri Net Approach (Computational Biology)” Book Review: This book presents a comprehensive overview of the applications of Petri nets in systems biology. Written by a team of international experts, the book begins with an introduction to systems biology, biochemistry foundations, and the basics of Petri net theory. The following chapters cover various Petri net modelling techniques for building and analyzing biological models, as well as network prediction approaches. The book also explores modular and qualitative modelling of regulatory networks, topological analysis of metabolic and regulatory networks, analysis of models of signalling networks, and conversion of logical networks into Petri nets. In addition, the book provides insight into discrete, stochastic, fuzzy, dynamic pathway, genetic regulatory network modelling, and quantitative analysis techniques. A glossary of concepts and notation is included for easy reference.

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7."A First Course in Systems Biology" by Eberhard Voit
“A First Course in Systems Biology” Book Review: This book provides a great introduction to the interdisciplinary field of systems biology. The book covers a broad range of topics, including molecular biology, biochemistry, genetics, and computer science. Starting with an overview of biological systems, the book goes on to discuss concepts such as mass balance analysis, enzyme kinetics, and metabolic pathways. It also delves into network and graph theory, systems dynamics, and the modeling of gene regulatory networks. The book is well-structured and easy to follow, making it ideal for both students and researchers interested in systems biology.

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8."Computational Systems Biology (Methods in Molecular Biology)" by Jason McDermott and Ram Samudrala
“Computational Systems Biology (Methods in Molecular Biology)” Book Review: This book discusses the field of computational systems biology, which employs computational methods to identify, model, and store relationships between molecules, pathways, and cells within living organisms. The book notes that this field has existed for some time and has expanded to include modeling of both small metabolic and signaling systems as well as relationships between components in larger systems such as whole cells and organisms. The models presented in this field provide an overview of various aspects of these systems, while the determination of specific details is left to experimentalists focused on smaller subsystems.

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3. Systems Biology

 
1."A First Course in Systems Biology" by Eberhard Voit
“A First Course in Systems Biology” Book Review: This book is for advanced undergraduate and graduate students who wish to develop computational models and apply them to diverse biological systems. It helps students retrieve, reformat, merge, and interpret complex biological information. It also provides the background and methods to execute standard systems biology tasks. It helps students understand modern literature by providing references to primary literature along with a set of small-scale exercises that enable hands-on experience. A larger-scale set of exercises have open-ended questions for further reflection. This book is useful for students who are interested in pursuing a career in computational systems biology or who want to use computational methods to understand biological systems.

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2."An Introduction to Systems Biology: Design Principles of Biological" by Uri Alon
“An Introduction to Systems Biology: Design Principles of Biological” Book Review: This book provides an overview of the design principles of biological systems, focusing on the recurring circuit elements that make up biological networks. It also provides a simple mathematical framework that can be used to understand and design biological circuits. The book focuses on several well-studied biological systems that concisely demonstrate key principles. This book builds a solid foundation for the intuitive understanding of general principles in system biology.

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3."Respiratory System: 1 (Human Body)" by Pegasus
“Respiratory System: 1 (Human Body)” Book Review: The book provides an in-depth understanding of the respiratory system in the human body. The book starts with the basics of respiration and anatomy of the respiratory system, including the structure and function of the nose, pharynx, larynx, trachea, bronchi, and lungs. It then covers the physiology of breathing, gas exchange, and respiratory regulation. Further chapters discuss respiratory diseases and disorders, such as asthma, COPD, and lung cancer. The book provides detailed illustrations and diagrams to aid understanding. This book is an informative and comprehensive guide to the respiratory system for students and enthusiasts alike.

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4."Systems Biology: Constraint-based Reconstruction and Analysis" by Bernhard Palsson
“Systems Biology: Constraint-based Reconstruction and Analysis” Book Review: This book explains how quantitative and computable genotype-phenotype relationships are established by using genome-wide data on the gene portfolio of a target organism. It also describes how biological knowledge is used to reconstruct biochemical reaction networks. The book further explains the formulation of computational models of biological functions and how these models can be used to answer key biological questions and enable predictive biology. It helps to provide students with a solid conceptual framework and a good set of modeling tools and computational approaches. It is a good resource for students studying system biology.

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5."Computational Systems Biology: From Molecular Mechanisms to Disease" by Andres Kriete and Roland Eils
“Computational Systems Biology: From Molecular Mechanisms to Disease” Book Review: The book covers the theoretical and experimental foundations of biological systems at various levels of organization, from molecular to organismal and over different time and space scales. Focusing on the engineering of biological systems and network modeling, it explains the basic building blocks of life and their impact on disease phenotypes. The book presents evolved principles that offer insight into the underlying organizational principles of biological systems and processes. It also covers technical tools and systems for researchers to address specific systems biology problems using advanced computation. The multi-scale modeling approach helps researchers understand the spatio-temporal relationships essential for biological organization and function. This book will benefit students studying systems biology.

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6."Foundations of Systems Biology" by Hiroaki Kitano
“Foundations of Systems Biology” Book Review: The goal of this book is to approach biological processes as integrated systems, rather than as independent components. It presents a comprehensive overview of the current state of the field, including central topics such as automated and comprehensive measurements, gene reverse engineering, metabolic network analysis based on experimental data, software challenges, modeling and simulation, and system-level analysis. This book is a valuable resource for researchers and practitioners in the field of systems biology seeking to deepen their understanding of the subject.

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7."Computational Approaches in Chlamydomonas reinhardtii for Effectual Bio-hydrogen Production (SpringerBriefs in Systems Biology)" by Pratyoosh Shukla and M V K Karthik
“Computational Approaches in Chlamydomonas reinhardtii for Effectual Bio-hydrogen Production (SpringerBriefs in Systems Biology)” Book Review: This book is a comprehensive guide to understanding the stability and interactions of HydA1 and PetF using molecular dynamics as a screening technique. The author uses a structure-based computational approach to recognize and characterize protein-protein complexes and their functions, highlighting the effectiveness of homology modeling for specific proteins and the usefulness of docking algorithms for explaining interactions in detail. The book is an invaluable resource for researchers in the fields of bio-hydrogen and bioinformatics, providing insights into biomass-based biofuels and introducing the model microorganism Chlamydomonas reinhardtii for biofuel production research. With its focus on in silico methods, such as phylogenetic studies, molecular docking, electrostatic studies, and conformational analysis, this book is a useful reference for senior undergraduate and graduate students, researchers, professionals, and anyone interested in bioenergy and microalgal biofuel.

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8."The Biology of Moral Systems (Evolutionary Foundations of Human Behavior Series)" by Richard Alexander
“The Biology of Moral Systems (Evolutionary Foundations of Human Behavior Series)” Book Review: According to this book, conflicts of interest give rise to moral questions. Moral systems, in turn, are utilized to reconcile these conflicts of interest at higher levels of social organization by aligning confluences of interest at lower levels. The author presents a general theory of human interests, utilizing biological senescence and effort theory to analyze the patterns of human life. The book argues that the ultimate interests of humans are reproductive and suggests that morality has emerged within groups due to its ability to foster unity and ultimately, success in intergroup competition. This work advances our understanding of evolution through natural selection and proposes practical solutions for our most challenging social problems. Biology students and teachers can use this book as a valuable resource.

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9."Systems Biology of Alzheimer's Disease (Methods in Molecular Biology)" by Juan I Castrillo and Stephen G Oliver
“Systems Biology of Alzheimer’s Disease (Methods in Molecular Biology)” Book Review: This book takes an integrated approach to studying Alzheimer’s Disease (AD) and presents Systems Biology as a new strategy for investigating multifactorial diseases. By using both experimental and computational approaches, the book aims to improve diagnosis and treatment, as well as public health policies. This book complements existing volumes and monographs on AD that focus on fundamental, physiological, or medical aspects of the disease. It is geared towards post-graduate students, post-doctoral researchers, and experts in various fields interested in comprehensive Systems Biology strategies applicable to AD and other complex multifactorial diseases, including neurodegenerative diseases and cancers.

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10."Big Mechanisms in Systems Biology: Big Data Mining, Network Modeling, and Genome-Wide Data Identification" by Bor-Sen Chen and Cheng-Wei Li
“Big Mechanisms in Systems Biology: Big Data Mining, Network Modeling, and Genome-Wide Data Identification” Book review: The book explores the concept of Big Mechanisms in systems biology and offers insights into big data mining, network modeling, and genome-wide data identification. It is a valuable resource for bioinformaticians and researchers in various biomedical fields who want to gain a comprehensive understanding of processing and applying large amounts of biological data to advance their research. The book covers a wide range of topics, including system immunity, regulation, infection, aging, evolution, and carcinogenesis, and includes over 140 diagrams to illustrate the Big Mechanism concept in systems biology.

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11."Control Theory and Systems Biology" by Pablo Iglesias and Ingalls B
“Control Theory and Systems Biology” Book Review: This book is intended for students studying biological and biochemical systems, covering a wide range of information from established material to recent developments in the field. It presents various modeling frameworks and their applications, providing insights into quantitative measures of dynamic behavior, modularity, stoichiometry, robust control techniques, and network identification. Whether you’re interested in traditional or modern approaches, this book offers valuable information for those looking to expand their knowledge of biological and biochemical systems.

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We have put a lot of effort into researching the best books on Systems Biology and came out with a recommended list and their reviews. If any more book needs to be added to this list, please email us. We are working on free pdf downloads for books on Systems Biology and will publish the download link here. Fill out this Systems Biology books pdf download" request form for download notification.

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