47 Best Books on Organic Synthesis

We have compiled a list of the Best Reference Books on Organic Synthesis, which are used by students of top universities, and colleges. This will help you choose the right book depending on if you are a beginner or an expert. Here is the complete list of Organic Synthesis Books with their authors, publishers, and an unbiased review of them as well as links to the Amazon website to directly purchase them. If permissible, you can also download the free PDF books on Organic Synthesis below.

1. Principles of Organic Synthesis

 
1."Organic Synthesis" by Matthys Levy and Mario Salvadori
“Organic Synthesis” Book Review: This book presents the fundamental concepts of organic synthesis. It covers topics such as functional groups, organic transformations, and oxidation-reduction reactions. A new chapter on retrosynthetic analysis of complex molecules has been added. Each unit of the book concludes with a comprehensive set of questions to enhance students’ understanding. With more than 600 reactions and figures, the concepts are presented in an easy-to-understand manner. This book is recommended for graduate-level students in chemistry and chemical engineering.

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2."Advanced Organic Chemistry" by F ACarey and R J Sundberg
“Advanced Organic Chemistry” Book Review: This book delves into the intricacies of advanced organic chemistry, covering both structure and mechanism as well as synthetic reactions. Divided into two parts, Part A focuses on the fundamental concepts of chemical bonding and molecular structure, including valence bond approach, stereochemical principles, dynamic stereochemistry, and steric effects. Part B covers synthetic reactions, organized by reaction type and including important reactions commonly used in organic synthesis. Each unit includes practice problems to reinforce learning. This book is an excellent resource for advanced level chemistry students, with a companion website offering additional exercises and materials for further study.

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3."Principles of Organic Synthesis" by Richard O C Norman and ‎James Morriss Coxon
“Principles of Organic Synthesis” Book Review: This book covers the fundamental principles of organic synthesis. It includes topics such as chemical thermodynamics, molecular structure, chemical kinetics, and reaction mechanisms. Other chapters discuss the formation of carbon-carbon bonds, aliphatic carbon-carbon bonds, and pericyclic reactions. All the reactions and equations are described in detail with proper labels. This book is recommended for students studying applied chemistry.

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4."advanced organic chemistry principles, tools and logic of synthesis" by R Balaji Rao
“advanced organic chemistry principles, tools and logic of synthesis” Book Review: This book provides a comprehensive guide to advanced organic chemistry and the logic of synthesis, along with its tools. The book covers important topics such as the synthesis of organic molecules, guidelines and rules governing organic synthesis, and the logic of synthesis. Additionally, the book also covers strategies in disparlure synthesis, menthol synthesis, and longifolene synthesis. The concepts are supported by figures and diagrams to aid in understanding. This book is recommended for advanced level chemistry and chemical engineering students.

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5."General Principles of Organic Syntheses" by P Alexeyeff
“General Principles of Organic Syntheses” Book Review: This book is designed for students interested in advanced organic chemistry, providing a theoretical foundation for the subject. It covers a range of topics related to organic synthesis, including main principles and techniques. Key chapters focus on the action of oxidizing agents, direct and indirect oxidation, reduction, substitution of other groups by hydrogen, fixation of hydrogen, and different types of synthesis. The book offers detailed explanations and examples of each topic, with a list of questions at the end of each chapter to help readers test their understanding. Written in a student-friendly manner, this book can also be used as a laboratory manual for the preparation of organic compounds. It is a valuable resource for advanced chemistry students and those interested in gaining a deeper understanding of organic synthesis.

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6."High-Throughput Synthesis: Principles and Practices" by Irving Sucholeiki
“High-Throughput Synthesis: Principles and Practices” Book Review: This book is focused on the methods utilized in high throughput synthesis. The book covers a variety of topics such as solid-phase organic synthesis, high-throughput synthesis for drug discovery, and the synthesis of new materials and catalysts. It is divided into four parts, with the first two parts discussing theory and methods for solid phase organic synthesis and high throughput synthesis for drug discovery, respectively. Part three covers the high throughput synthesis of new materials and catalysts, while part four delves into new directions in high throughput synthesis. The chapters feature numerous case studies that provide a clear understanding of the topics. The book emphasizes the need for detailed experiment reproduction. This book is suitable for advanced chemistry students seeking to expand their knowledge in high throughput synthesis.

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7."Strategies and Tactics In Organic Synthesis" by Thomas Lindberg
“Strategies and Tactics in Organic Synthesis” Book Review: The strategies and tactics employed in organic synthesis are discussed in this book. It covers a variety of topics such as solving complex stereochemical problems with molecular mechanics, synthesis of cembranoid natural products, and the Champagne route to avermectins and milbemycins. There are 13 chapters, each written by different scientists and researchers, providing examples to explain the concepts. This book is designed for graduate level chemistry students.

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8."Organic Synthesis Through Disconnection Approach" by P S Kalsi
“Organic Synthesis Through Disconnection Approach” Book Review: This book adopts a disconnection approach to study organic synthesis. It covers a range of topics, including organic reactions, retrosynthetic analysis, selectivity, and specificity. The book also discusses the synthesis of ring systems, protection and deprotection of functional groups, and synthesis of carbonyl compounds. The text contains a variety of problems with corresponding answers to aid in comprehension. It provides essential information on the subject and is ideal for postgraduate students of chemistry. The book emphasizes the approach leading to organic synthesis, facilitating easy understanding of the concepts. Diagrams and figures are used where necessary to clarify the topics. The book is highly recommended for advanced chemistry students.

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9."Organic Synthesis: Concepts And Methods" by Fuhrhop J
“Organic Synthesis: Concepts and Methods” Book Review: This book outlines the fundamental principles of organic synthesis. The primary topics covered in this book are the synthesis of carbon chains, functional group interconversion, carbo-cycles, heterocycles, and arenes. Additionally, it discusses combinational mixtures and selection, biopolymers, dendrimers, and concepts in nanometer-sized skeletons and modules. At the end of the book, conclusions are provided in alphabetical order. This book is designed for advanced chemistry and chemical engineering students.

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10."Organic Synthesis : Special Techniques" by V K Ahluwalia
“Organic Synthesis: Special Techniques” Book Review: This book presents alternative techniques for organic synthesis that use fewer hazardous chemicals. It is intended for senior undergraduates, graduates, and scientists. The book covers various special techniques used in organic synthesis, including phase transfer catalyst, Crown ethers, microwave-induced organic synthesis, and sonochemistry. Other topics discussed include Polymer supported reagents and synthesis, synthetic applications, and nomenclature. Each chapter includes a summary of miscellaneous reactions and conclusions for quick review. References are also included for further reading. The book provides a detailed discussion of all methodologies and techniques. It is beneficial for Masters, PhD, and research scientists in the field of chemistry. This book is particularly useful for students at the Masters or PhD level.

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11."Reaction Mechanisms in Organic Synthesis (Postgraduate Chemistry Series)" by Rakesh Kumar Parashar
“Reaction Mechanisms in Organic Synthesis (Postgraduate Chemistry Series)” Book Review: This book offers an in-depth review of the reaction mechanisms involved in organic synthesis, assuming the reader has a basic understanding of the concepts. It delves deeply into transition metal mediated carbon-carbon bond formation reactions and covers advanced topics such as the use of oxidation and reduction reagents and stabilized carbanions. This book is tailored to students, teachers, and professionals in the field of engineering and science, particularly chemical engineering.

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2. Techniques for Organic Synthesis

 
1."Distinctive Techniques for Organic Synthesis" by Tse-Lok Ho
“Distinctive Techniques for Organic Synthesis” Book Review: This book is aimed at professionals in the field of synthetic chemistry. It covers a wide range of topics, including reactions conducted under high pressure, those mediated by ultrasonic and flash vacuum pyrolysis, photochemical processes, phase transfer reactions, electrochemical reactions, and reactions on solid supports. The book provides numerous real-world examples to highlight the practical applications of these topics.

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2."Techniques in Organic Chemistry" by Jerry R Mohrig
“Techniques in Organic Chemistry” Book Review: The book provides an extensive overview of laboratory techniques available to students studying organic chemistry. It includes detailed instructions for working with various types of laboratory glassware, including mini-scale, standard-taper microscale, and Williamson microscale. Additionally, the book emphasizes the importance of safety in the laboratory and covers a range of spectroscopic techniques.

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3."Modern Methods of Organic Synthesis" by W Carruthers
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4."Organic Synthesis" by Douglass F Taber and Tristan Lambert
“Organic Synthesis” Book Review: This book presents the latest advancements in organic synthesis, covering a range of topics from functional group conversions to the synthesis of complex natural products. The book is divided into two sections: the first section covers specific topics such as C-N ring construction and carbon-carbon bond formation, with journal references included in the text. The second section is dedicated to total synthesis and discussions of key transformations. With its comprehensive coverage and practical insights, this book is a valuable resource for both students and practicing chemists.

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5."Reduction: Techniques and Applications in Organic Synthesis" by Robert L Augustine
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6."Green Techniques for Organic Synthesis and Medicinal Chemistry" by Wei Zhang and Berkeley Cue
“Green Techniques for Organic Synthesis and Medicinal Chemistry” Book Review: The main focus of this book is the application of green chemistry principles in organic synthesis, drug discovery, and medicinal chemistry. It provides comprehensive coverage of various novel and sustainable techniques and their respective limitations. The book also covers green concepts and catalysis, with case studies that demonstrate practical applications in the pharmaceutical industry. It is an essential resource for professionals and students interested in sustainable chemistry practices.

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7."Organic Synthesis" by Douglass Taber
“Organic Synthesis” Book Review: This book delves into crucial topics of organic synthesis, including novel techniques for C-C bond formation, asymmetric organocatalysis, and direct C-H functionalization. It offers a comprehensive evaluation of the significance and usefulness of each innovative synthetic method. Moreover, it features an in-depth analysis of over twenty complex total syntheses, such as the Sammakia synthesis of the Macrolide RK-397, the Ley synthesis of Rapamycin, and the Kobayashi synthesis of Norzoanthamine. This book is an essential resource for chemists and students in the field of organic synthesis.

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8."Advanced Organic Synthesis: Methods and Techniques" by Richard Monson
“Advanced Organic Synthesis: Methods and Techniques” Book Review: This book provides a methodical introduction to the latest techniques used in organic synthesis. It covers the equipment, terminology, and procedures involved in synthetic processes. It explains the range and mechanism of chemical reactions, as well as technical procedures for conducting experiments. The book is aimed at advanced undergraduate or new graduate students of chemistry.

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9."The Organic Chemistry of Drug Synthesis" by Daniel Lednicer and Lester A Mitscher
“The Organic Chemistry of Drug Synthesis” Book Review: This book offers a comprehensive guide to the synthetic procedures utilized for the production of various therapeutic agents. It covers the disease state, method of drug therapy, biological activities, and preparation of each compound. The book concludes with a glossary that defines biological terms. It is a valuable resource for those in the pharmaceutical industry and researchers in medicinal chemistry.

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3. Organometallic Strategies in Organic Synthesis

 
1."Transition Metal Reagents and Catalysts- Innovation in Organic Synthesis" by J Tsuji
“Transition Metal Reagents and Catalysts- Innovation in Organic Synthesis” Book Review: This book explores the applications and chemistry of transition metal reagents and catalysts. It includes discussions on pioneering industrial processes that use homogeneous transition metal catalysts, the basics of transition metal complexes, and various reaction patterns. Chapters are dedicated to reactions involving organic halides and pseudo halides, allylic compounds, and conjugated dienes. Protection and activation by coordination, reactions catalyzed by pd (II) compounds, and other topics are also covered in detail, with numerous examples and equations provided for clarity. This book is ideal for advanced chemistry students seeking a deeper understanding of transition metal chemistry.

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2."Transition Metals for Organic Synthesis- Building Blocks and Fine Chemicals Vol. I and II" by M Beller and C Bolm
“Transition Metals for Organic Synthesis- Building Blocks and Fine Chemicals Vol. I and II” Book Review: This book provides an overview of the applications of transition metals in organic synthesis. It covers major topics such as the formation of carbon-carbon bonds, reduction, oxidation, hydroformylation, and cyclopropanation. It also includes discussions on the Heck reaction, Suzuki reaction, and transfer hydrogenation. The information in each chapter is presented in tables for easy reference. This book is a valuable resource for students of organic chemistry.

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3."Transition Metals in the Synthesis of Complex Organic Molecules" by L S Hegedus
“Transition Metals in the Synthesis of Complex Organic Molecules” Book Review: This book provides an in-depth coverage of the concepts of organic chemistry in transition metals. It includes major chapters on formalism, electron counting, bonding, and reaction mechanisms. Other topics discussed are the synthetic applications of transition metal hydrides, the applications of complexes containing metal-carbon-S bonds, and the synthetic applications of transition metal arena complexes. Numerous equations are provided to aid in understanding the concepts. This book is recommended for students studying organic chemistry.

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4."Strategies and Tactics in Organic Synthesis" by Michael Harmata Dr
“Strategies and Tactics in Organic Synthesis” Book Review: This book outlines the strategies and tactics for inorganic synthesis. It covers major topics such as the spiroketalization method for cortatarian A, developing new synthesis of alkaloid galantamine, and discodermolide. Other topics discussed include exploring infections caused by Mycobacterium ulcerans and total synthesis of the fungal metabolite virgatolide B. The book includes conclusions and future prospects at the end of each chapter, with detailed equations and information provided throughout. It is a valuable resource for advanced chemistry students.

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5."Introduction Organometallic Chemistry" by Parkins
“Introduction Organometallic Chemistry” Book Review: This book serves as an introductory guide to organometallic chemistry. It covers various topics such as the preparation of organometallic compounds, the structure and bonding in organometallic compounds, and the use of organometallic compounds as a source of carbanions. The book also explores the reactions of organic groups bonded to metals, the coordination chemistry of organometallic compounds, and carbene chemistry. The methods and equations used are discussed in detail with examples to support the concepts. Additionally, the book includes references and suggested reading for each chapter to aid in further review and study. This book is suitable for undergraduate chemistry students.

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6."Organic Synthesis: Strategy and Control" by Paul Wyatt and Stuart Warren
“Organic Synthesis: Strategy and Control” Book Review: This book is a comprehensive guide to organic synthesis and its strategies, organized into five sections for easy comprehension of the concepts. The major topics covered include selectivity, carbon-carbon bond formation, stereochemistry, and carbon-carbon double bonds. Each chapter is accompanied by numerical problems for practice, and extensive and up-to-date references are provided. The book offers practical approaches to compound synthesis, with examples to illustrate key concepts. It is intended for students and professional chemists familiar with organic synthesis. Additionally, it includes discussions on the functional group strategy.

The book deals with selectivity, carbon-carbon single bonds and carbon-carbon double bonds. It also covers stereochemistry, and functional group strategy.

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7."Stereoselectivity in Organic Synthesis" by Garry Procter
“Stereoselectivity in Organic Synthesis” Book Review: This book is focused on stereoselective organic synthesis and covers important reaction mechanisms. The main chapters include the stereochemistry of reactions, addition reactions to carbonyl compounds, and reactions of enolates. Additionally, the book discusses reduction, oxidation, rearrangements, hydrolysis, and esterification. Each chapter provides practical examples and numerical problems with their respective solutions at the end of the book. This book is suitable for advanced level chemistry students seeking to improve their understanding of stereoselective organic synthesis.

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8."Organic Synthesis: The Disconnection Approach" by Stuart Warren and Paul Wyatt
“Organic Synthesis: The Disconnection Approach” Book Review: This book discusses various topics related to organic synthesis, including the disconnection approach, chemo-selectivity, amine synthesis, and the use of acetylene. It also covers topics such as controlling carbonyl condensations, utilizing aliphatic nitro compounds in synthesis, and radical reactions in synthesis. The book contains additional examples, problems, and solutions to aid in understanding. All diagrams are clearly labeled, and a formula index for all molecular formulas is provided. This book is recommended for advanced chemistry students.

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4. Strategies and Methods in Organic Synthesis

 
1."Organic Synthesis" by Michael B Smith
“Organic Synthesis” Book Review: This book offers an overview of functional groups, followed by a detailed review of fundamental organic transformations such as oxidation and reduction. The book further delves into reactions for carbon-carbon bond formation and methods for deconstructing larger molecules into simpler building blocks. Each chapter concludes with a series of questions designed to test the reader’s comprehension. The book also covers retrosynthetic analyses of complex molecules. It is intended for graduate and postgraduate students, as well as scientific researchers in chemistry.

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2."Organic Chemistry" by J Clayden
“Organic Chemistry” Book Review: The book provides a comprehensive overview of organic chemistry, covering organic structure and molecules, as well as organic reactions, delocalization, conjugation, acidity, basicity, and pK. It also explores equilibria, stereochemistry, elimination reactions, and alkylation of enolates. Additionally, the book discusses reactions and synthesis of aromatic heterocycles, stereoselectivity, and retrosynthetic analysis. The content is presented in a student-friendly manner and includes 3D animation links. Each chapter ends with a range of problems for students to test their understanding. This book is suitable for undergraduate and graduate chemistry students.

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3."Organic Synthesis: Concepts And Methods" by Fuhrhop J
“Organic Synthesis: Concepts And Methods” Book Review: The book is an introductory guide to organic synthesis. It covers a wide range of topics, including carbon chain synthesis, carbocycles, and functional group interconversion. Additionally, it delves into heterocycles, arenes, biopolymers, dendrimers, combinatorial mixtures, and selection. The book also covers concepts in nanometer and retrosynthetic analysis. To aid further research, the book includes a reference list. It is written in a clear and accessible style for students.

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5. Reagents in Organic synthesis

 
1."Some Modern Methods of Organic Synthesis" by W Carruthers
“Some Modern Methods of Organic Synthesis” Book Review: The book focuses on the contemporary techniques of organic synthesis. It covers key topics such as the creation of carbon-carbon single bonds, carbon-carbon double bonds, Diels-Alder, and other related reactions. Additionally, it delves into the reactions at unactivated C-H bonds, and the synthetic applications of organoboranes and organosilanes. The book also includes discussions on oxidation and reduction. Equations are meticulously elucidated with supporting examples. This book is highly recommended for advanced chemistry students.

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2."Name Reactions and Reagents in Organic Synthesis" by Dr S Renuga
“Name Reactions and Reagents in Organic Synthesis” Book Review: The book comprehensively covers the name reactions and reagents used in organic synthesis. It starts with a section on acronyms and abbreviations commonly used in organic synthesis. This is followed by detailed descriptions of various name reactions used in organic synthesis, including the associated agents and their acronyms. The final chapter is dedicated to name reagents and their acronyms. The book provides thousands of reactions and names in a detailed manner with accompanying figures. It is a valuable resource for students studying organic chemistry, including those pursuing B.Sc., postgraduate, and competitive examinations.

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3."Application of Redox and Reagents in Organic Synthesis: Volume I" by Ramendra Kumar Kar
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4."A Guide to Reagents in Organic Synthesis" by Vinod Jena
“A Guide to Reagents in Organic Synthesis” Book Review: The book provides a comprehensive overview of reagents used in organic synthesis. It covers topics such as Gilman’s reagent, lithium dimethyl cuprate, lithium diisopropylamide, and trimethylsilyl. Other topics covered in the book include Osmium tetroxide, Selenium dioxide, phase transfer catalysts, Crown ethers, and Merrifield resin. The book includes a good number of practice problems to help students improve their understanding of the reagents. Each topic is thoroughly explained with examples. This book is ideal for advanced chemistry students and those preparing for competitive examinations.

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5."Organozinc Reagents in Organic Synthesis" by Ender Erdik
“Organozinc Reagents in Organic Synthesis” Book Review: The book covers the application of organozinc reagents in organic synthesis. It contains chapters on the structure and reactivity of organozinc reagents, their preparation, and their addition to carbon-carbon multiple bonds. In addition, the book discusses the addition of organozinc reagents to carbonyl and carbon-nitrogen multiple bonds. The equations are explained in detail with examples. This book is recommended for advanced chemistry students.

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6."Organophosphorus Reagents in Organic Synthesis" by J I G Cadogan
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7."Microbial Reagents in Organic Synthesis" by Stefano Servi
“Microbial Reagents in Organic Synthesis” Book Review: The focus of this book is on the application of microbial reagents in organic synthesis. The main topics covered include carbon-carbon bond formation, synthetic applications, and the use of hydrolytic and proteolytic enzymes. The book also covers oxidations, reductions, and useful enzymes from plant cells and organ cultures. Each chapter has been written by different contributors, whose names can be found at the end of the book. The equations and methods are explained in detail, making it useful for advanced chemistry students.

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6. Enzymes in Organic Synthesis

 
1."Enzymes in Synthetic Organic Chemistry " by C H Wong and G H Whitesides
“Enzymes in Synthetic Organic Chemistry” Book Review: The focus of this book is on the development of organic enzymatic synthesis using isolated enzymes. It covers a range of topics including techniques for enzyme immobilization and stabilization, the use of enzymes under extreme conditions, and modification of enzyme properties through chemical means. The book also delves into site-directed mutagenesis. Scientists working in the field of Organic Chemistry will find this book beneficial.

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2."Biotransformations in Organic Chemistry" by Kurt Faber
“Biotransformations in Organic Chemistry” Book Review: The book presents an accessible introduction to biocatalysis, which provides a powerful toolkit for selective transformations in modern preparative organic chemistry. It covers a range of topics, including the rules of stereoselective transformations, enzyme kinetics, enzyme nomenclature, and enzyme handling. This book is tailored for undergraduate and graduate students studying biocatalysis.

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3."Enzyme Catalysis in Organic Synthesis" by Karlheinz Drauz
“Enzyme Catalysis in Organic Synthesis” Book Review: This book is a comprehensive guide to the application of enzymes in organic chemistry. The book covers a range of topics such as enzyme mechanisms, enzyme nomenclature, and methods for enzyme immobilization. It also discusses the application of enzymes in different types of organic reactions, including hydrolysis, oxidation, reduction, and C-C bond formation. The book includes numerous examples of enzyme catalyzed reactions, along with detailed reaction schemes and mechanisms. This book is a valuable resource for researchers and students interested in organic synthesis and enzymology.

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4."Enzymes in Organic Synthesis" by CIBA
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5."Organic Synthesis with Enzymes in Non–Aqueous Media" by Giacomo Carrea and Sergio Riva
“Organic Synthesis with Enzymes in Non–Aqueous Media” Book Review: The book provides an in-depth discussion of synthetic applications using non-aqueous systems. It covers topics such as non-aqueous enzymology, synthetic applications based on hydrolases, and non-hydrolytic enzymes. The book also includes numerous examples of synthetic processes, including those used in pharmaceutical and fine chemical industries. This book is a valuable resource for researchers and professionals working in synthetic organic chemistry.

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6."New Enzymes for Organic Synthesis: Screening, Supply and Engineering" by Thomas Scheper
“New Enzymes for Organic Synthesis: Screening, Supply and Engineering” Book Review: This book explores the enzymatic synthesis of useful compounds. It explains how isolated enzymes can be utilized to synthesize complex molecules. The book covers various topics such as screening of novel enzymes, their biochemical characterization, and approaches to reaction engineering to enhance their performance. It will be a valuable resource for organic chemists, industry chemists, and those interested in stereochemistry.

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7."Enzymes as Catalysts in Organic Synthesis" by Manfred P Schneider
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8."ENZYMES: Biochemistry, Biotechnology, Clinical Chemistry" by Trevor Palmer and Philip Bonner
“ENZYMES: Biochemistry, Biotechnology, Clinical Chemistry” Book Review: This book is a comprehensive book covering the principles of enzymology and its applications. The book covers topics ranging from enzyme kinetics, structure, and function, to the various techniques used in enzyme research. It also discusses enzyme biotechnology, including enzyme engineering, immobilization, and biocatalysis. Additionally, the book provides insights into the role of enzymes in clinical chemistry and diagnosis, including their use as diagnostic markers for various diseases. This book will be beneficial for students and researchers interested in enzymology, biotechnology, and clinical chemistry.

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9."Principles of Enzyme Technology" by M Y Khan and Farha Khan
“Principles of Enzyme Technology” Book Review: This book provides a comprehensive presentation of Enzyme Technology principles, covering a variety of topics such as Enzyme Environment, Enzyme Purification, Enzyme Mobilization, and Enzyme Control. It also delves into the inhibition of enzymes, multi-substrate reactions, and representative enzyme response mechanisms. Designed for students in biotechnology and biochemistry, this book provides an exhaustive guide to Enzyme Technology.

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We have put a lot of effort into researching the best books on Organic Synthesis and came out with a recommended list and their reviews. If any more book needs to be added to this list, please email us. We are working on free pdf downloads for books on Organic Synthesis and will publish the download link here. Fill out this Organic Synthesis books pdf download" request form for download notification.

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